{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:54:48Z","timestamp":1762808088163},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T00:00:00Z","timestamp":1320796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: The Multicentre registry with Antiplatelet TReatment two\u2013sIX months (MATRIX) evaluated safety and efficacy at 12\u2010month follow\u2010up of Janus Flex stenting with 2\u2010 or 6\u2010month dual antiplatelet therapy (DAT) period. <jats:styled-content>Background<\/jats:styled-content>: There are no data of Janus Flex stent (Carbostent and Implantable Devices\u2014CID, Saluggia, Italy), a polymer\u2010free, tacrolimus\u2010eluting coronary stent, followed by short\u2010term DAT, in daily practice. <jats:styled-content>Methods<\/jats:styled-content>: Patients were prospectively enrolled at 12 high\u2010volume procedures centres. After stenting, four sites prescribed 2\u2010month DAT, eight sites 6\u2010month DAT. Major adverse cardiac events (MACE) and stent thrombosis (ST) rate was evaluated at 12\u2010month follow\u2010up, for entire population, as well as for 2\u2010 and 6\u2010month DAT groups, distinctly. MACE included cardiac death, myocardial infarction (MI), and target lesion revascularization (TLR). <jats:styled-content>Results<\/jats:styled-content>: From March 2007 to June 2008, 572 patients (mean age 64.91 \u00b1 11 years, 77.45% males) were enrolled. After successful stenting, 12\u2010month follow\u2010up showed a 12.74% MACE occurrence (cardiac death 0.98%; MI 3.13%; TLR 8.62%), with good Janus Flex safety profile confirmed by only two (0.39%) ST. After adjustment for potential confounding, no significant differences were noted at 12\u2010month follow\u2010up among 2\u2010 or 6\u2010month DAT groups (MACE\u20148.99% versus 12.47%, <jats:italic>P<\/jats:italic> = 0.16; cardiac death\u20140.54% versus 1.14%, <jats:italic>P<\/jats:italic> = 0.52; MI\u20142.38% versus 2.71%, <jats:italic>P<\/jats:italic> = 0.83; TLR\u20145.66% versus 10.60%, <jats:italic>P<\/jats:italic> = 0.20; ST\u20140% versus 0.55%, <jats:italic>P<\/jats:italic> = 0.99). At multivariable analysis, DAT time duration was not an independent risk factor for adverse events (adjusted HR 0.47, 95% confidence interval 0.16\u20131.35, <jats:italic>P<\/jats:italic> = 0.16). <jats:styled-content>Conclusions<\/jats:styled-content>: Janus Flex coronary stenting, followed by short DAT, is safe and feasible, without differences between 2\u2010 and 6\u2010month DAT groups. A randomized trial confirming these encouraging data is needed. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23223","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T19:18:43Z","timestamp":1309979923000},"page":"408-416","source":"Crossref","is-referenced-by-count":4,"title":["Reduced antiplatelet therapy after drug\u2010eluting stenting: Multicenter janus flex carbostent implantation with short dual antiplatelet treatment for 2 or 6 months\u2014matrix study"],"prefix":"10.1002","volume":"80","author":[{"given":"Salvatore","family":"Cassese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Villari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Bellone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Alfieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Montinaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Quaranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Marraccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Piscione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of MATRIX Study Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm064"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.09.012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675934"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.015"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp337"},{"key":"e_1_2_7_11_2","first-page":"127","article-title":"Properties of a new carbon film for biomedical applications","volume":"9","author":"Paccagnella A","year":"1986","journal-title":"Int J Artif Organs"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8183.2003.01050.x"},{"key":"e_1_2_7_13_2","first-page":"45","article-title":"Direct stenting of de novo coronary stenoses with tacrolimus\u2010eluting versus carbon\u2010coated carbostents. 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