{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:26:35Z","timestamp":1760016395623},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objective<\/jats:styled-content>: We describe the short\u2010term results of the patients who underwent transapical treatment of a paravalvular leak (PVL) in our centre.<\/jats:p><jats:p><jats:styled-content>Background<\/jats:styled-content>: Increasing experience with transapical aortic valve implantation has inspired us to explore this approach for prosthetic paravalvular leak reduction in high risk patients.<\/jats:p><jats:p><jats:styled-content>Methods<\/jats:styled-content>: All procedures were performed in the catheterization laboratory under general anesthesia, using a small anterolateral thoracotomy to expose the apex. Access through a 9\u2010French sheath was necessary to introduce the Amplatzer Vascular III plug. Three\u2010dimensional transesophageal echocardiography (3D\u2010TEE) was used to guide the operator and evaluate the severity of regurgitation postimplantation.<\/jats:p><jats:p><jats:styled-content>Results<\/jats:styled-content>: In total seven consecutive patients (mean age 72.8 \u00b1 5.6 years, 86% male) with a history of mitral valve (<jats:italic>n<\/jats:italic> = 6) or aortic valve replacement and severe PVL, underwent transapical PVL reduction using seven plugs in total (diameter 10\u201314 mm). Preprocedural median logistic EuroSCORE was 28.5% (range 17.1\u201341.1%) and NYHA functional class was \u22653 in all patients. The procedure was successful in all patients, with a median fluoroscopic time of 18.7 min (range 10.1\u201329.6 min). Postprocedure 3D\u2010TEE showed occlusion of PVL in three patients, and significant reduction in three patients. Postprocedural complication was a hematothorax requiring surgery in one patient. Median hospitalization duration after the procedure was 5 days (range 5\u201359 days). At 3\u2010month follow\u2010up one patient died, functional class and LDH did not differ significantly and there was a significant increase in hemoglobin.<\/jats:p><jats:p><jats:styled-content>Conclusions<\/jats:styled-content>: Transapical paravalvular leak reduction might be a good or rather attractive alternative in high\u2010risk patients for major re\u2010do cardiac surgery. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23264","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T16:16:56Z","timestamp":1311956216000},"page":"741-747","source":"Crossref","is-referenced-by-count":24,"title":["Transapical treatment of paravalvular leaks in patients with a logistic euroscore of more than 15%"],"prefix":"10.1002","volume":"79","author":[{"given":"Martin J.","family":"Swaans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn C.","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A. Johan","family":"van der Ven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin H.","family":"Heijmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Budts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurien M.","family":"ten Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.09.21"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.176857"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(91)90105-S"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00358-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.014"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90250-Q"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1112"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.052"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.09.028"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2007.00343.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20795"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(09)71671-8"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21270"},{"key":"e_1_2_6_15_2","first-page":"305","article-title":"Percutaneous closure of perivalvular leaks with Amplatzer occluders: Feasibility, safety, and shortterm results","volume":"16","author":"Shapira Y","year":"2007","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00174.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21542"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21939"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.04.013"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.07.057"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22807"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.23264","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.23264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T09:24:53Z","timestamp":1700558693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.23264"}},"subtitle":["Acute and 3\u2010month outcomes of a \u201cproof of concept\u201d study"],"short-title":[],"issued":{"date-parts":[[2012,1,10]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/ccd.23264"],"URL":"https:\/\/doi.org\/10.1002\/ccd.23264","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,10]]}}}