{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:39:48Z","timestamp":1761561588079},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> To evaluate the effect of a polymer\u2010free Biolimus A9\u2010eluting stent [BioFreedom\u2122 (BF)], compared with that of a biodegradable polymer\u2010based Biolimus A9\u2010eluting stent [BioMatrix Flex\u2122 (BMF)] and a bare metal stent (BMS) in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. <jats:styled-content>Methods:<\/jats:styled-content> Rabbits were fed with 1% cholesterol diet (<jats:italic>n<\/jats:italic> = 14) for 14 days, both iliac arteries were balloon denuded and radiated, and then rabbits were switched to 0.15% cholesterol diet. After 4 weeks, BF (<jats:italic>n<\/jats:italic> = 8), BMF (<jats:italic>n<\/jats:italic> = 8), and BMS (<jats:italic>n<\/jats:italic> = 8) were deployed in denuded and radiated areas. Four weeks later animals were euthanized, arterial segments were processed for morphometry. <jats:styled-content>Results:<\/jats:styled-content> The neointimal area in vessels implanted with BF stents was significantly less than that seen in vessels implanted with BMS (0.90 mm<jats:sup>2<\/jats:sup> \u00b1 0.14 vs. 1.29 mm<jats:sup>2<\/jats:sup> \u00b1 0.23, <jats:italic>P<\/jats:italic> &lt;0.01). Percent fibrin and fibrin score were higher with BMF stents compared to BMS (<jats:italic>P<\/jats:italic> &lt;0.03 and &lt;0.04) and giant cell number was significantly higher with both BMF and BF stents (<jats:italic>P<\/jats:italic> &lt; 0.01 for both). Percent endothelialization was significantly higher and % uncovered struts were lower with BMS compared to either BMF or BF stents (<jats:italic>P<\/jats:italic> &lt; 0.05 for both). <jats:styled-content>Conclusion:<\/jats:styled-content> This study demonstrates that compared to BMS, BF stents significantly decreased neointimal hyperplasia. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.23407","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T06:46:25Z","timestamp":1321944385000},"page":"429-436","source":"Crossref","is-referenced-by-count":9,"title":["In vivo comparison of a polymer\u2010free Biolimus A9\u2010eluting stent with a biodegradable polymer\u2010based Biolimus A9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac 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