{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:50:16Z","timestamp":1761663016504},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> To determine the prevalence of impaired left ventricular (LV) systolic function and its impact on the in\u2010hospital and long\u2010term outcome in patients who underwent Transcatheter Aortic Valve Implantation (TAVI). <jats:styled-content>Background:<\/jats:styled-content> Although impaired LV function may be considered a contra\u2010indication for aortic valve replacement, the hemodynamic characteristics of transcatheter valves may offer procedural and long\u2010term clinical benefit in such patients. <jats:styled-content>Methods:<\/jats:styled-content> 230 consecutive patients underwent TAVI with the Medtronic\u2010CoreValve System. Impaired LV function was defined by a Left Ventricular Ejection Fraction (LVEF) \u2264 35% (European Multicenter Study on Operative Risk Stratification and Long\u2010term Outcome in patients with Low\u2010Flow\/Low\u2010Gradient Aortic Stenosis). Study endpoints were selected and defined according to the Valve Academic Research Consortium recommendations. <jats:styled-content>Results:<\/jats:styled-content> Compared with patients with a LVEF &gt; 35% (<jats:italic>n<\/jats:italic> = 197), those with LVEF \u2264 35% (<jats:italic>n<\/jats:italic> = 33) were more often male (78.8 % vs. 46.7%, <jats:italic>P<\/jats:italic> &lt; 0.001), more symptomatic (NYHA class III or IV, 97.0% vs. 77.2%, <jats:italic>P<\/jats:italic> = 0.008) and had a higher prevalence of prior coronary artery disease (63.6% vs. 43.1%, <jats:italic>P<\/jats:italic> = 0.029). The Logistic EuroSCORE was 14.8% and 22.8, respectively (<jats:italic>P<\/jats:italic> = 0.012). No difference was observed between the two groups in in\u2010hospital or 30\u2010day mortality (3.0% vs. 9.6%, <jats:italic>P<\/jats:italic> = 0.21), the Combined Safety Endpoint at 30 days (24.2% and 24.4%, <jats:italic>P<\/jats:italic> = 0.99) and survival free from readmission at one year (69.2% and 69.7%, <jats:italic>P<\/jats:italic> = 0.85). After adjustment, LVEF \u2264 35% was not associated with an increased risk of 30\u2010day mortality, in\u2010hospital complications and survival free from readmission at follow\u2010up. <jats:styled-content>Conclusion:<\/jats:styled-content> The immediate and long\u2010term outcome after TAVI did not differ between patients with an impaired and preserved LVEF. LVEF \u2264 35% did not predict adverse immediate and long\u2010term outcome. These findings suggest that TAVI should not be withheld in selected patients with impaired LV function. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23423","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T06:17:21Z","timestamp":1322201841000},"page":"702-710","source":"Crossref","is-referenced-by-count":33,"title":["Clinical outcome following transcatheter aortic valve implantation in patients with impaired left ventricular systolic function"],"prefix":"10.1002","volume":"79","author":[{"given":"Robert M.","family":"van der Boon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutger\u2010Jan","family":"Nuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis 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