{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:51:48Z","timestamp":1788580308144,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:bold>Objectives<\/jats:bold><\/jats:title><jats:p>We studied outcomes of neonatal aortic valvuloplasty to determine the risk factors for poor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Background<\/jats:bold><\/jats:title><jats:p>Balloon aortic valvuloplasty (BAV) is the primary therapy for neonates with severe aortic stenosis (AS). Limited data are available on the mid\u2010term and long\u2010term outcomes in this population, and reported risk factors for poor outcomes vary among studies.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Methods<\/jats:bold><\/jats:title><jats:p>We reviewed all cases of BAV in neonates in our institution between 1998 and 2009. We reviewed patient characteristics, preintervention echocardiographic, and procedural details. We tracked repeat BAV, aortic valve replacement (AVR), and death\/transplant. Kaplan\u2013Meier and Cox regression analyses were performed. Changes in dimensions of left heart structures post\u2010BAV were also studied.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Results<\/jats:bold><\/jats:title><jats:p>Forty\u2010eight neonates were included\u2014of these, 30 (62%) had critical AS. There was one procedural death. The remaining 47 neonates were followed for 4.8 \u00b1 4.4 years. Repeat BAV was performed in 19 (40%) neonates; AVR was performed in 9 (19%), and death\/transplant occurred in 4 (8%) neonates. Multivariate analysis revealed that lower LV shortening fraction pre\u2010BAV, higher pre\u2010BAV and final valve gradient, and need for inotropes were associated with poor long\u2010term outcomes. LV diastolic and systolic dimensions normalized over time, and left heart structures improved in size early and late after BAV.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Conclusions<\/jats:bold><\/jats:title><jats:p>Neonatal BAV is associated with low mortality. Lower LV shortening fraction pre\u2010BAV is associated with risk of future interventions, while repeat valvuloplasty is safe and effective for recurrent AS. There is significant improvement in dimensions of the LV and aortic valve annulus following BAV. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.23500","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T18:45:58Z","timestamp":1334688358000},"page":"1190-1199","source":"Crossref","is-referenced-by-count":18,"title":["Diminished left ventricular function is associated with poor mid\u2010term outcomes in neonates after balloon aortic valvuloplasty"],"prefix":"10.1002","volume":"80","author":[{"given":"Christopher J.","family":"Petit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F.","family":"Ing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Mattamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo H.","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Justino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.70.6.546"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89395-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951109990308"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.687764"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70183-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00497-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.082"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153809.88286.2E"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.2.351"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1531"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70152-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01144.2004"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00266-0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20424"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80430-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90268-4"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.831"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90850-9"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.03.098"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00268-9"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.03.050"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00067-2"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.05.049"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.848994"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.23500","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.23500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:47:09Z","timestamp":1700596029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.23500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,17]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/ccd.23500"],"URL":"https:\/\/doi.org\/10.1002\/ccd.23500","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,17]]}}}