{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:22:33Z","timestamp":1777904553960,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T00:00:00Z","timestamp":1343692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the technique of ultrasound (US)\u2010guided percutaneous thrombin\u2013gelatin injection for the treatment of femoral artery pseudoaneurysms (FAPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>FAPs are a possible complication from percutaneous angiographic procedures. US\u2010guided thrombin injection is currently the preferential therapeutic option, limited by a low risk of potentially catastrophic femoral thrombosis; transluminal injection of collagen is another effective and safe option, although a more invasive one; surgical repair is associated with significant comorbidity. We hypothesized that US\u2010guided combined thrombin and gelatin injection (UG\u2010TGI) would also be effective while minimizing the risk of limb thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Review of the results, complications and length of hospital admission after the injection into the FAP sac of combined human\u2010origin thrombin and bovine\u2010origin gelatin matrix (FloSeal<jats:sup>\u00ae<\/jats:sup>, Baxter), under direct US\u2010guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We treated 13 patients (mean age 64 \u00b1 9.46 years, 38% male), who developed a FAP following a percutaneous procedure: isolated coronariography in five (38%); angioplasty in four (31%); other cardiac procedures in four (31%). Immediate success was obtained in all (100%) patients, assessed by US; no allergic reactions, local infection, or embolic events occurred on 30\u2010day follow\u2010up. Median (interquartile range) admission time after the UG\u2010TGI was 2 days (1.25\u20132.0); median time of total admission was 8 days (6.5\u201316.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this small study, UG\u2010TGI for the treatment of FAP was feasible and had short\u2010term effectiveness, without a learning curve effect. Despite the need for further experience, a trial comparing different therapies for FAP should include this procedure. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24330","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T23:14:52Z","timestamp":1343776492000},"page":"303-307","source":"Crossref","is-referenced-by-count":10,"title":["Ultrasound\u2010guided thrombin\u2013gelatin injection is effective for the treatment of iatrogenic femoral artery pseudoaneurysms: Initial results"],"prefix":"10.1002","volume":"81","author":[{"given":"Miguel Borges","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Cardiology Santa Cruz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Egas Moniz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Egas Moniz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Campante","family":"Teles","sequence":"additional","affiliation":[{"name":"Department of Cardiology Santa Cruz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Sousa","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Santa Cruz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duarte","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Egas Moniz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Aniceto","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Cardiology Santa Cruz Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.138.2.7455105"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(88)80002-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90677-Q"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(91)90226-K"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400340033006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20534"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.681973"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000071089.76348.6A"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2008.07.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.5.01841665"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.36.2.96"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV3I3A59"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01752-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(94)90119-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70209-X"},{"key":"e_1_2_6_17_1","first-page":"3","article-title":"Diagnosis and treatment of iatrogenic femoral artery pseudoaneurysms","volume":"21","author":"Middleton WD","year":"2005","journal-title":"Ultrasound Q"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.2.7824703"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.6.10584803"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I4A70"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.71.852.10318997"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.74.884.740690"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.1.r00ja04127"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61284-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01194-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-001-0073-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.47.462"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200108010-00002"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.24330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.24330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:34:45Z","timestamp":1700663685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.24330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,31]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/ccd.24330"],"URL":"https:\/\/doi.org\/10.1002\/ccd.24330","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,31]]}}}