{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:07:23Z","timestamp":1791410843588,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T00:00:00Z","timestamp":1335916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess long\u2010term outcome after rotational atherectomy (RA) is followed by drug\u2010eluting stent (DES) implantation in complex calcified coronary lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>RA can favorably modify heavily calcified coronary lesions, but long\u2010term outcome is poor when it is used as a stand\u2010alone therapy or combined with bare\u2010metal stents. DES have reduced rates of restenosis in a wide range of patient and lesion subsets, but little information is available on long\u2010term clinical outcome when RA is followed by DES implantation (Rota\u2010DES) in complex calcified lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Two hundred and five patients with de novo complex calcified coronary lesions treated with Rota\u2010DES were analyzed. Mean age was 69.7 \u00b1 9.3 years, 63 patients (31%) had diabetes mellitus and 21 patients (10%) had chronic renal failure. Total stent length\/patient was 32 mm. The majority of patients were treated with paclitaxel\u2010eluting stents (64%) or sirolimus\u2010eluting stents (30%). Angiographic success rate was 98%. The incidence of in\u2010hospital major adverse cardiac events (MACE), defined as death, myocardial infarction (MI), and target vessel revascularization (TVR), was 4.4%. Long\u2010term follow\u2010up was available for 188 patients (92%). At a median follow\u2010up period of 15 months (range, 1\u201384), the cumulative incidence of MACE (Kaplan\u2013Meier estimate) was 17.7%. Death occurred in 4.4%, MI in 3.4%, TVR in 9.9%, and target lesion revascularization (TLR) in 6.8%. One definite (0.5%) and one probable (0.5%) stent thrombosis were observed. In a multivariate analysis, low ejection fraction (&lt;40%) was the only independent predictor of MACE, and both age and diabetes were independent predictors of TLR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study represents the largest European data set of patients treated with RA in the DES era. RA followed by DES implantation in calcified coronary lesions appears to be feasible and effective, with a high rate of procedural success and low incidence of TLR and MACE at long term considering this complex patient and lesion subset. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24367","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T19:35:43Z","timestamp":1331926543000},"page":"285-291","source":"Crossref","is-referenced-by-count":87,"title":["Long\u2010term clinical outcome of rotational atherectomy followed by drug\u2010eluting stent implantation in complex calcified coronary lesions"],"prefix":"10.1002","volume":"81","author":[{"given":"Mohamed","family":"Abdel\u2010Wahab","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart Center Segeberger Kliniken GmbH (Academic Teaching Hospital of the Universities of Kiel and Hamburg) Bad Segeberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoy","family":"Baev","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Segeberger Kliniken GmbH (Academic Teaching Hospital of the Universities of Kiel and Hamburg) Bad Segeberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dieker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Segeberger Kliniken GmbH (Academic Teaching Hospital of the Universities of Kiel and Hamburg) Bad Segeberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Kassner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Segeberger Kliniken GmbH (Academic Teaching Hospital of the Universities of Kiel and Hamburg) Bad Segeberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed 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