{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:25:15Z","timestamp":1761863115698},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited data on the optimal management of in\u2010stent restenosis after percutaneous coronary intervention (PCI) with bare metal stent (BMS) or drug\u2010eluting stent (DES) implantations. We assessed the clinical presentation, the incidence, and prognosis of definite stent thrombosis or restenosis after DES implantation for treatment of restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2002 to June 2005, all consecutive patients with restenosis &lt; 12 months after index PCI with DES or BMS implantation, were identified in the population\u2010based Western Denmark Heart Registry. Patients were followed until 24 months after their first restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 589 lesions were treated for clinically driven restenosis with target lesion revascularization (TLR) within 12 months after the index PCI. Among those, 302 lesions were treated with DES (BMS\u2010restenosis <jats:italic>n<\/jats:italic> = 244 and DES\u2010restenosis <jats:italic>n<\/jats:italic> = 58). Admission were due to stable angina pectoris (<jats:italic>n<\/jats:italic> = 249 (82.4%)), unstable angina pectoris (<jats:italic>n<\/jats:italic> = 34 (11.3%)), or non\u2010ST segment elevation myocardial infarction (<jats:italic>n<\/jats:italic> = 19 (6.3%)). The clinical indication was not different between patients with BMS restenosis compared to DES restenosis. In the BMS restenosis group, older age, longer lesion, longer stent length, and a higher number of stents used was observed compared to the DES restenosis group. After a first restenosis, clinically driven re\u2010TLR was seen in 26 (8.6%) patients within the following 24 months, stent thrombosis (median duration 155 days, interquartile range (IQR) 9\u2013627 days) was seen in 3 lesions (1.0%), and secondary restenosis (median duration 168 days, IQR 88\u2013266 days) was seen in 23 (7.6%) [DES restenosis group 6.9% vs. BMS restenosis group 7.8%, <jats:italic>P<\/jats:italic> = 0.818] lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical presentation did not differ between BMS or DES and most patients present with stable angina pectoris. Risk of stent thrombosis or restenosis was not increased in patients with DES restenosis compared to patients with BMS restenosis treated with DES. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24398","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T10:26:17Z","timestamp":1334744777000},"page":"260-265","source":"Crossref","is-referenced-by-count":9,"title":["Incidence of definite stent thrombosis or in\u2010stent restenosis after drug\u2010eluting stent implantation for treatment of coronary in\u2010stent restenosis: From Western Denmark heart registry"],"prefix":"10.1002","volume":"81","author":[{"given":"Jesper Khedri","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Flensted","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Henrik","family":"Tilsted","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aalborg Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knud Noerregaard","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense 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