{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:27:03Z","timestamp":1780064823826,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate the efficacy and safety of paclitaxel\u2010coated balloon plus bare\u2010metal stenting (BMS) in chronic total occlusions (CTOs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010eluting stent implantation after recanalization of CTOs is limited by the occurrence of restenosis and risk for late stent thromboses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, bicenter trial we treated 48 patients after successful chronic total occlusion (CTO) recanalization in a native coronary artery with paclitaxel\u2010coated balloon plus BMS. Patients were matched according to stent length, reference diameter, and diabetes mellitus with 48 patients treated with Taxus stent implantation. Dual antiplatelet therapy was prescribed for 6 months. Angiographic (clinical) follow\u2010up was obtained after 6 (12) months. Primary endpoint was in\u2010stent late lumen loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in patient baseline characteristics or procedural results. Stent length was 59.7 \u00b1 32.4 mm (16\u2013151 mm) for paclitaxel\u2010coated balloon plus BMS versus 56.2 \u00b1 25.9 mm (16\u2013132 mm) for Taxus stent. Late loss was statistically not different within the stent with 0.64 \u00b1 0.69 mm versus 0.43 \u00b1 0.64 mm (difference 0.20 mm, 95% confidence interval \u22120.07 to 0.47, <jats:italic>P<\/jats:italic> = 0.14) and at the occlusion site with 0.33 \u00b1 0.69 mm versus 0.26 \u00b1 0.70 mm, respectively. Restenosis rate was 27.7% compared with 20.8% (<jats:italic>P<\/jats:italic> = 0.44) and the combined clinical endpoint (cardiac death, myocardial infarction attributed to the target vessel, target lesion revascularization) was 14.6% versus 18.8% (<jats:italic>P<\/jats:italic> = 0.58), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, for patients with complex CTOs in native coronary arteries the use of paclitaxel\u2010coated balloon after bare\u2010metal stenting was associated with similar clinical results and a nonsignificantly higher in\u2010stent late loss compared with a matched population with paclitaxel\u2010eluting stent implantation (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT00670436). \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24409","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T10:26:58Z","timestamp":1334744818000},"page":"793-799","source":"Crossref","is-referenced-by-count":33,"title":["Paclitaxel\u2010coated balloon with bare\u2010metal stenting in patients with chronic total occlusions in native coronary arteries"],"prefix":"10.1002","volume":"81","author":[{"given":"Jochen","family":"W\u00f6hrle","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S.","family":"Werner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Klinikum Darmstadt GmbH Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.040"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.613588"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061254"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.839282"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-009-0101-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.226563"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.092214"},{"key":"e_1_2_5_12_1","first-page":"135","article-title":"Long\u2010term 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