{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:05Z","timestamp":1786977365886,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    Percutaneous coronary intervention (PCI) is frequently accompanied by myocardial injury. The present study was performed to determine whether remote ischemic preconditioning (IP) induces cardioprotection during PCI.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We enrolled 95 patients requiring nonemergency PCI for stable disease or unstable angina into this prospective clinical trial. Patients were randomized to either remote IP (induced by three 3\u2010min cycles of blood pressure cuff inflations to 200 mm Hg around the upper arm, followed by 3\u2010min of reperfusion\n                    <jats:italic>n<\/jats:italic>\n                    = 47) or sham control (\n                    <jats:italic>n<\/jats:italic>\n                    = 48) immediately preceding PCI. The primary outcome measure was the frequency of post\u2010PCI myonecrosis, defined as a peak postprocedural cTnT\n                    <jats:italic>T<\/jats:italic>\n                    \u22650.03 ng\/dL. Secondary outcome measures were the change in plasma high\u2010sensitivity C\u2010reactive protein (hsCRP) levels following PCI and in endothelial progenitor cells (EPC) counts following IP.\n                    <jats:bold>Results:<\/jats:bold>\n                    There was no difference in the primary endpoint of the frequency of PCI related myonecrosis which occurred in 22 (47%) and 19 (40%) patients in the remote IP and control groups, respectively,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.42. There was significant increase in hsCRP post\u2010PCI in both groups (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), but there was no difference between the groups (median %change in hsCRP 46% vs. 54%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.73). There was no significant change in circulating early (CD34 \u2212\/CD133+\/KDR+), intermediate (CD34+\/CD133+\/KDR+), or late (CD34+\/CD133\u2212\/KDR+) EPC in the two groups immediately following IP. The composite rate of death, myocardial infarction, and target lesion revascularization at 1 year was 14.1% versus 13.7% (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.90).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Our study indicates that remote IP immediately before PCI does not induce cardioprotection in low to moderate risk patients. \u00a9 2012 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ccd.24443","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T08:13:53Z","timestamp":1334823233000},"page":"930-936","source":"Crossref","is-referenced-by-count":58,"title":["Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: A single center randomized sham controlled trial"],"prefix":"10.1002","volume":"81","author":[{"given":"Abhiram","family":"Prasad","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"G\u00f6ssl","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hoyt","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Polk","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Simari","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"David R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases and Department of Internal Medicine Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912134"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.765610"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.814640"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.3.893"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn114"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.809723"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157144.24888.7E"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000043806.51912.9B"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.044"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2193"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.5.1641"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00559-2"},{"key":"e_1_2_8_15_1","first-page":"1821","article-title":"Increased C reactive protein and cardiac enzyme levels after coronary stent implantation","volume":"92","author":"Iliodromitis EK","year":"2006","journal-title":"Is there protection by remote ischaemic preconditioning? Heart"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.11.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00046.2004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.08.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62001-8"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.24443","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.24443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:16:38Z","timestamp":1700594198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.24443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,8]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1002\/ccd.24443"],"URL":"https:\/\/doi.org\/10.1002\/ccd.24443","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,8]]}}}