{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:59:40Z","timestamp":1763704780302},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Paravalvular aortic insufficiency (AI) is observed in the majority of patients undergoing transcatheter aortic valve replacement (TAVR). While paravalvular AI is most commonly modest following TAVR, moderate or severe AI was seen in 10.5% and 6.8% of the PARTNER inoperable and high\u2010risk cohorts at 1 year and has been reportedly associated with dyspnea and diminished survival. We report two cases of transcatheter heart valve (THV) associated paravalvular defects closed using catheter delivered devices. Both patients derived hemodynamic and symptomatic improvement from device closure. Additional research is warranted to define the adverse consequences of THV associated AI, indications for treatment, and risks associated with device closure of these defects. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.24477","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T10:09:11Z","timestamp":1336990151000},"page":"901-905","source":"Crossref","is-referenced-by-count":19,"title":["Device closure of paravalvular defects following transcatheter aortic valve replacement with the Edwards Sapien valve"],"prefix":"10.1002","volume":"81","author":[{"given":"Brian","family":"Whisenant","sequence":"first","affiliation":[{"name":"Intermountain Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Jones","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Horton","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Horton","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.857"},{"key":"e_1_2_6_5_1","first-page":"300","article-title":"Early left ventricular remodeling in acute severe aortic regurgitation: insights from an animal model","volume":"17","author":"Lachance D","year":"2008","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.782292"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.217158"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"e_1_2_6_9_1","first-page":"260","article-title":"Hemolysis after transcatheter balloon expandable aortic valve insertion","volume":"23","author":"Murphy CJ","year":"2007","journal-title":"Can J Cardiol"},{"key":"e_1_2_6_10_1","volume-title":"Transcatheter Aortic Valve Implantation: Tips and Tricks to Avoid Failure","author":"Serruys PW","year":"2010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.03.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.03.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22168"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22199"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.24477","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.24477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:17:30Z","timestamp":1700612250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.24477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/ccd.24477"],"URL":"https:\/\/doi.org\/10.1002\/ccd.24477","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,9]]}}}