{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:17:24Z","timestamp":1791915444920,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T00:00:00Z","timestamp":1343865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We performed microscopic examination of the debris collected by a distal protection device and investigated the usefulness of grayscale and integrated backscatter intravascular ultrasound (IB\u2010IVUS) for the prediction of distal embolization during percutaneous coronary intervention (PCI) in cases of unstable angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The prediction of distal embolization during PCI has not been studied in depth because assessment of distal embolization is difficult.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively studied 39 consecutive patients with unstable angina who underwent PCI with a filter distal protection device. The preprocedural plaque volume at target lesions was measured with grayscale IVUS and plaque characteristics were assessed with IB\u2010IVUS. We performed microscopic examination of the particles collected by the distal protection device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant correlation between the plaque volume and the number of the collected particles &gt;100 \u03bcm in diameter (<jats:italic>r<\/jats:italic> = 0.48, <jats:italic>P<\/jats:italic> = 0.0034). Filter no\u2010reflow (FNR) phenomenon was found in nine patients. The plaque volume was significantly greater (355 \u00b1 133 mm<jats:sup>3<\/jats:sup> vs. 199 \u00b1 90 mm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.0004), and the lipid ratio was significantly higher (29.3 \u00b1 4.3% vs. 26.1 \u00b1 4.3 <jats:italic>P<\/jats:italic> = 0.045) in the FNR group compared with the non\u2010FNR group. Multivariate logistic regression analysis showed that the plaque volume was an independent predictor of FNR phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although tissue characterization of IB\u2010IVUS may provide additional information for distal embolization, plaque volume is the only significant predictor of distal embolization during PCI. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24559","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T17:25:24Z","timestamp":1341595524000},"source":"Crossref","is-referenced-by-count":17,"title":["Prediction of distal embolization during percutaneous coronary intervention for unstable plaques with grayscale and integrated backscatter intravascular ultrasound"],"prefix":"10.1002","volume":"81","author":[{"given":"Masahiko","family":"Shibuya","sequence":"first","affiliation":[{"name":"Cardiovascular Division Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Okamura","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoo","family":"Date","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nagai","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makito","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuomi","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02040-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(84)80234-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066695.24697.07"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015697.59592.07"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn248"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.044"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017200.47342.10"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.2.410"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I8A151"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.05.071"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01175-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000097121.95451.39"},{"key":"e_1_2_8_16_1","first-page":"509","article-title":"Role of adenosine in hyperemic response of coronary blood flow in microembolization","volume":"250","author":"Hori M","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_8_17_1","first-page":"1565","article-title":"Human monocyte\u2010derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. 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