{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T17:39:32Z","timestamp":1748367572143},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Balloon aortic valvuloplasty (BAV) is the primary therapy for congenital aortic stenosis (AS). Recurrent AS following initial BAV or initial surgical valvotomy (SV) may require a second BAV (BAV2). We sought to determine the longterm outcomes of BAV2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We reviewed all cases of BAV2, defined as BAV following primary BAV or SV between 1988 and 2009. Cases were reviewed for pre\u2010 and post\u2010BAV2 echocardiographic and procedural details.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care dedicated children's hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Between 1985 and 2009, 43 patients underwent BAV2 (23 primary SV, 20 primary BAV) at median age 1.9 years (1 month\u201321 years) and median weight 15 (3.3\u201355) kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>BAV2 performed following primary SV or primary BAV. Main Outcome<\/jats:p><\/jats:sec><jats:sec><jats:title>Measures<\/jats:title><jats:p>We evaluated the following endpoints: \u2265 moderate AI post\u2010BAV2, aortic valve replacement (AVR), additional BAV or SV post\u2010BAV2, death and heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gradient decreased from 61.4 \u00b1 16.0 mm Hg to 26.0 \u00b1 13.6 post\u2010BAV2 (<jats:italic>P<\/jats:italic> &lt; 0.01). Gradient prior to BAV2 was higher in primary SV patients (66 \u00b1 13 mm Hg) than in primary BAV patients (56 \u00b1 18 mm Hg, <jats:italic>P<\/jats:italic> = 0.04). 24 patients had no further events after BAV2, while 19 patients (44%) experienced 23 events including: AVR (<jats:italic>n<\/jats:italic> = 8), SV (<jats:italic>n<\/jats:italic> = 6), BAV3 (<jats:italic>n<\/jats:italic> = 2), death (<jats:italic>n<\/jats:italic> = 5), and transplant (<jats:italic>n<\/jats:italic> = 1). Regression demonstrated that adverse events were associated with higher post\u2010BAV2 gradient (<jats:italic>P<\/jats:italic> &lt; 0.01). Repeat intervention on the aortic valve and AVR were associated with higher post BAV2 gradient (<jats:italic>P<\/jats:italic> = 0.04, <jats:italic>P<\/jats:italic> = 0.01). Prior to BAV2, 7 patients (17%) had AI &gt; mild, compared to 21 (51%) patients after BAV2. Cox regression revealed that primary BAV was associated with development of AI &gt; mild after BAV2 (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BAV2 is associated with decreased valve gradient, though with an increase in AI. However, residual AS, not AI, is associated with poor outcomes following BAV2. BAV2 effectively treats recurrent AS and postpones need for surgical intervention. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24562","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T20:05:35Z","timestamp":1342814735000},"page":"549-555","source":"Crossref","is-referenced-by-count":14,"title":["Repeat balloon aortic valvuloplasty effectively delays surgical intervention in children with recurrent aortic stenosis"],"prefix":"10.1002","volume":"82","author":[{"given":"Christopher J.","family":"Petit","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Lillie Frank Abercrombie Section of Cardiology Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiraz A.","family":"Maskatia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Lillie Frank Abercrombie Section of Cardiology Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Justino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Lillie Frank Abercrombie Section of Cardiology Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael J.","family":"Mattamal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Lillie Frank Abercrombie Section of Cardiology Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Crystal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Lillie Frank Abercrombie Section of Cardiology Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank F.","family":"Ing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Lillie Frank Abercrombie Section of Cardiology Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.082"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153809.88286.2E"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.05.040"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.687764"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.2.351"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.040"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951109990308"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00067-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90269-6"},{"issue":"1","key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"I152","DOI":"10.1161\/hc37t1.094837","article-title":"Are 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