{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:32:16Z","timestamp":1764603136413},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>The purpose of this study was to understand why patients with adult congenital heart disease (CHD) but no obvious shunt have an increased frequency of migraine headaches (MH). CHD patients with no known cardiac shunts (CHD\u2010NKS), based on their echocardiographic or angiographic procedures, were tested for a right\u2010to\u2010left shunt using agitated saline contrast transcranial Doppler (TCD). Medical records of 2,920 patients from the UCLA Adult CHD Center were screened to participate in a study to evaluate the prevalence of MH in adults with CHD; 182 patients (6.23%) had CHD\u2010NKS; of these, 60 (30%) underwent a TCD; 23 (38%) tested positive and 37 (62%) tested negative for a right\u2010to\u2010left shunt (<jats:italic>P<\/jats:italic> = 0.01 compared with controls). The frequency of MH was 43% in CHD\u2010NKS compared with 11% in controls (<jats:italic>P<\/jats:italic> &lt; 0.0001). TCD demonstrated right\u2010to\u2010left shunting in approximately 2\/3 of patients with pulmonary stenosis, the Marfan syndrome and congenitally corrected transposition of great vessels, 1\/4 of patients with bicuspid aortic valve, 1\/5 of patients with mitral valve prolapse and all patients with Ebstein's anomaly. Approximately half of these experienced MH. Patients who had MH did not show a higher frequency of right\u2010to\u2010left shunt when compared with patients without MH (<jats:italic>P<\/jats:italic> = <jats:italic>0<\/jats:italic>.57). In conclusion, CHD patients with conditions usually not associated with a shunt have a higher than expected prevalence of PFO which permits intermittent right\u2010to\u2010left shunting undetected by standard non\u2010contrast TTE and TEE; the increased prevalence of right\u2010to\u2010left shunting may partially explain the higher than expected frequency of migraines. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.24635","type":"journal-article","created":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T09:53:39Z","timestamp":1345888419000},"page":"643-647","source":"Crossref","is-referenced-by-count":7,"title":["Incidence of patent foramen ovale and migraine headache in adults with congenital heart disease with no known cardiac shunts"],"prefix":"10.1002","volume":"81","author":[{"given":"Marat","family":"Volman","sequence":"first","affiliation":[{"name":"Program in Interventional Cardiology Division of Cardiology David Geffen School of Medicine University of California at Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Khalid","family":"Mojadidi","sequence":"additional","affiliation":[{"name":"Program in Interventional Cardiology Division of Cardiology David Geffen School of Medicine University of California at Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubine","family":"Gevorgyan","sequence":"additional","affiliation":[{"name":"Program in Interventional Cardiology Division of Cardiology David Geffen School of Medicine University of California at Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Kaing","sequence":"additional","affiliation":[{"name":"Program in Interventional Cardiology Division of Cardiology David Geffen School of Medicine University of California at Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsh","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Program in Interventional Cardiology Division of Cardiology David Geffen School of Medicine University of California at Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Tobis","sequence":"additional","affiliation":[{"name":"Program in Interventional Cardiology Division of Cardiology David Geffen School of Medicine University of California at Los Angeles California"},{"name":"Consultant AGA Medical Inc., W.L. Gore Inc., Coherex Inc"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.01.062"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22826"},{"key":"e_1_2_6_4_1","first-page":"651415","article-title":"Prevalence in size of directly detected patent foramen ovale in migraine with aura","author":"Schwerzman M","year":"2005","journal-title":"Neurology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(01)90035-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.8.1622"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20000231"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015875"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.075"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.12.054"},{"key":"e_1_2_6_11_1","first-page":"362","article-title":"Does patent foramen ovale promote cryptogenic stroke and migraine headaches?","volume":"32","author":"Tobis JM","year":"2005","journal-title":"TX Heart Inst J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.047"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.12.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2004.tb00261.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00179008"},{"key":"e_1_2_6_16_1","unstructured":"Prospective Randomized Investigation to Evaluate Incidence of Headache Reduction in Subjects with Migraine and PFO Using the AMPLATZER PFO Occluder to Medical Management. January 2006\u2010January 2013.ClinicalTrials.govIdentifier: NCT00355056."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/383707a0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.506311"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.24635","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.24635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:04:02Z","timestamp":1700672642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.24635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,14]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/ccd.24635"],"URL":"https:\/\/doi.org\/10.1002\/ccd.24635","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,14]]}}}