{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:44:58Z","timestamp":1762955098658},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Older patients and diabetes mellitus (DM) are rapidly increasing in Western world populations. The treatment of coronary artery disease in these patients is challenging because they are complex and at high risk. Performance of the two widely used drug\u2010eluting stents (DES), i.e. sirolimus\u2010 (SES) and paclitaxel\u2010eluting stent (PES), is understudied in this subset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to explore the impact of the first generation DES choice on mid term outcome in a large and unselected population of diabetic patients older than 65 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>From a multicenter registry of 2,429 diabetic patients treated with sirolimus\u2010 (SES) or paclitaxel\u2010eluting stent (PES), 1,417 patients \u226565 years old were analyzed overall and separately for groups aged 65\u201374 (67%) and \u226575 (33%) years old. SES (55%) were compared to PES (45%) in terms of major adverse cardiac events, including all\u2010cause death, myocardial infarction (MI) and target lesion revascularization (TLR) throughout 1\u2010to\u20105 year follow\u2010up (median time 24 months). We failed to find at the unadjusted and adjusted analyses statistically significant differences in term of outcome between the two DES, both in the overall cohort and in the two different aged subgroups, also regardless of the insulin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this real\u2010life multicenter registry, PES and SES showed a comparable safety and efficacy profile in diabetic patients older than 65 years throughout 1\u2010to\u20105 years follow\u2010up. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24636","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T08:49:45Z","timestamp":1346402985000},"page":"1117-1124","source":"Crossref","is-referenced-by-count":4,"title":["Paclitaxel\u2010 and sirolimus\u2010eluting stents in older patients with diabetes mellitus"],"prefix":"10.1002","volume":"81","author":[{"given":"Paolo","family":"Buja","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Facchin","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Ospedali Riuniti di Bergamo Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Chiara","family":"Frigo","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Bologna, Policlinico S. Orsola\u2010Malpighi Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Menozzi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Cardiologia Dipartimento Cardio\u2010Polmonare Azienda Ospedaliero\u2010Universitaria di Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Meliga","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Mauriziano Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Sardella","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrologic, and Geriatric Sciences, Sapienza University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Cardiology Department Ferrarotto Hospital University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"101","article-title":"Centers for disease control and prevention: Trends in aging\u2014United States and worldwide","volume":"52","author":"Goulding MR","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_3_1","volume-title":"2006 Chart Book on Cardiovascular and Lung Diseases","author":"Incidence and Prevalence","year":"2006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S2118"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.4.518"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.781138"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.182615"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1348"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.057"},{"key":"e_1_2_6_11_1","first-page":"404","article-title":"Drug\u2010eluting stents in the elderly: Long\u2010term (> one year) clinical outcomes of octogenarians in the DESIRE (drug eluting stents in the real world) registry","volume":"20","author":"Costa JR","year":"2008","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_12_1","article-title":"Paclitaxel versus sirolimus eluting stents in diabetic patients: Does stent type and\/or stent diameter matter? 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