{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:41:18Z","timestamp":1761561678708},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T00:00:00Z","timestamp":1350259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to compare the efficacy and safety of intracoronary (IC) nitroprusside and intravenous adenosine (IVA) for assessing fractional flow reserve (FFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>IV infusion of adenosine is a standard method to achieve a coronary hyperemia for FFR measurement. However, adenosine is expensive, causes multiple side effects, and is contraindicated in patients with reactive airway disease. Sodium nitroprusside (NTP) is a strong coronary vasodilator but its efficacy and safety for assessing FFR is not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared FFR response and side effects profile of IC NTP and IVA. Bolus of NTP at a dose of 100 \u03bcg and IVA (140 \u03bcg\/kg\/min) were used to achieve coronary hyperemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We evaluated 75 lesions in 53 patients (60% male) mean age 61.6 \u00b1 13.9 years. Mean FFR after NTP was similar to FFR after adenosine (0.836 \u00b1 0.107 vs. 0.856 \u00b1 0.106; <jats:italic>P<\/jats:italic> = 0.26; <jats:italic>r<\/jats:italic> = 0.91, <jats:italic>P<\/jats:italic> &lt; 0.001). NTP induced maximal stable hyperemia within 10 sec (mean: 6.4 \u00b1 1) which lasted consistently between 38 and 60 sec (mean 51 \u00b1 7.5). NTP caused significant (14%), but asymptomatic decrease in mean blood pressure which returned to baseline within 60 sec. Adenosine caused shortness of breath in 26%, headache and flushing in 19%, and transient second degree heart block in 6% of patients. No adverse symptoms were reported after NTP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IC NTP is as effective as IVA for measuring FFR. NTP is better tolerated by patients. Since NTP is inexpensive, readily available, well tolerated, and safe, it may be a better choice for FFR assessment. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24652","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T14:09:24Z","timestamp":1347026964000},"page":"540-544","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of efficacy and safety of intracoronary sodium nitroprusside and intravenous adenosine for assessing fractional flow reserve"],"prefix":"10.1002","volume":"81","author":[{"given":"Wojciech","family":"Rudzinski","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology New Jersey Medical School University Hospital Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso H.","family":"Waller","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology New Jersey Medical School University Hospital Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Rusovici","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology New Jersey Medical School University Hospital Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abed","family":"Dehnee","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology New Jersey Medical School University Hospital Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Nasur","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology New Jersey Medical School University Hospital Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology New Jersey Medical School 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