{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:03:07Z","timestamp":1761807787712},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study used iMap IVUS system to compare neointimal tissue components between DES and bare\u2010metal stents (BMSs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010eluting stents (DESs) can cause impaired arterial healing, which constitutes the most important pathological substrate underlying late DES thrombosis. Intravascular ultrasound (IVUS)\u2010based tissue characterization allows for the <jats:italic>in vivo<\/jats:italic> identification of neointimal tissue components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Follow\u2010up IVUS data after coronary stenting (9.8\u2009\u00b1\u20099.4 months from index procedures) was obtained from consecutive 61 lesions (34 in DES, 27 in BMS). The iMap tissue components (fibrotic, lipidic, necrotic, and calcified) were measured in every recorded frame and expressed as percentages of mean neointimal cross\u2010sectional area for the stented segment. Patients' characteristics were comparable between DES and BMS. When compared with BMSs, smaller (2.9\u2009\u00b1\u20090.4 mm vs. 3.2\u2009\u00b1\u20090.4 mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) and longer (34\u2009\u00b1\u200918 mm vs. 26\u2009\u00b1\u200914 mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) DESs were implanted. When compared with BMS group, minimum lumen area at follow\u2010up was significantly greater in DES group (3.9\u2009\u00b1\u20091.8 mm<jats:sup>2<\/jats:sup> vs. 3.1\u2009\u00b1\u20091.5 mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04), mainly attributable to suppression of neointimal hyperplasia (1.7\u2009\u00b1\u20090.8 mm<jats:sup>2<\/jats:sup> vs. 3.1\u2009\u00b1\u20091.5 mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The iMap analyses showed that neointima after DES placement was composed of smaller fibrotic component (67\u2009\u00b1\u20098% vs. 78\u2009\u00b1\u20097%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), larger necrotic (14\u2009\u00b1\u20094% vs. 9\u2009\u00b1\u20093%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and calcified (15\u2009\u00b1\u20096% vs. 7\u2009\u00b1\u20094%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) components compared with BMS. Logistic regression analysis showed that only intra\u2010DES neointima was a significant predictor of necrotic neointima at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DES implantation would be associated with iMap\u2010derived necrotic and less\u2010fibrotic neointimal formation. <jats:italic>In vivo<\/jats:italic> iMap evaluation of neointimal tissue may provide useful information in detecting impaired healing after stenting. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24907","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:19:09Z","timestamp":1362435549000},"page":"1068-1074","source":"Crossref","is-referenced-by-count":4,"title":["Neointimal tissue component assessed by tissue characterization with 40 MHz intravascular ultrasound imaging: Comparison of drug\u2010eluting stents and bare\u2010metal stents"],"prefix":"10.1002","volume":"82","author":[{"given":"Kenichi","family":"Tsujita","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kaikita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Hokimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Horio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Mizobe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto 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