{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T19:05:17Z","timestamp":1722884717952},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We compare clinical outcomes among unselected patients undergoing percutaneous coronary intervention (PCI) with drug\u2010eluting stents (DES) stratified in categories of treating hospital PCI volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous observational evidence suggests an inverse relation between hospital volume and patients' outcomes. However, there are no mid\u2010term outcomes data with the use of DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from DES.DE (German Drug\u2010Eluting Stent) registry to compare in\u2010hospital and 1\u2010year outcomes among unselected patients. Primary endpoints at one year follow\u2010up were the rate of major adverse cardiac and cerebrovascular events (MACCE) and target vessel revascularization (TVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2005 and 2006, 2,075 patients were treated in group I hospitals (&lt;1,000 PCIs\/year), 1,624 in group II hospitals (1,000\u20131,500 PCIs\/year), and 1,790 in group III hospitals (&gt;1,500 PCIs\/year). Compared with group II and group III, group I allocation was associated with higher rates of overall hospital mortality (1.1% versus 0.2% versus 0.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and severe bleeding (1.0% versus 0.4% versus 0.5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); similarly, poorer outcomes with respect to MACCE (7.2% versus 6.5% versus 4.7%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), stent thrombosis (5.2% versus 5.0% versus 3.0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and non\u2010fatal stroke (1.5% versus 0.9% versus 0.7%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were documented in group I. Conversely, TVR rates were highest in group II (10.2% versus 14.2% versus 11.7%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01); these differences persisted after risk adjustment for heterogeneous baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the era of modern coronary intervention technological advances such as DES have not offset the inverse relation between procedural volume and both in\u2010hospital and 1\u2010year outcomes after PCI. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.24986","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T05:37:55Z","timestamp":1368596275000},"source":"Crossref","is-referenced-by-count":5,"title":["Volume\u2013outcomes relationship in the Era of modern coronary intervention\u2014results from the prospective multicenter German DES.DE Registry"],"prefix":"10.1002","volume":"82","author":[{"given":"Ibrahim","family":"Akin","sequence":"first","affiliation":[{"name":"Heart Center Rostock Divisions of Cardiology, Pulmology and Intensive Care Unit, Department of Internal Medicine I University Hospital Rostock  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Hochadel","sequence":"additional","affiliation":[{"name":"IHF Ludwigshafen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Schneider","sequence":"additional","affiliation":[{"name":"IHF Ludwigshafen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdel\u2010Wahab","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Bad Segeberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Zahn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Ludwigshafen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[{"name":"IHF Ludwigshafen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Richardt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Bad Segeberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Hospital Hamburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph A.","family":"Nienaber","sequence":"additional","affiliation":[{"name":"Heart Center Rostock Divisions of Cardiology, Pulmology and Intensive Care Unit, Department of Internal Medicine I University Hospital Rostock  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the DES.DE Study 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