{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:23:41Z","timestamp":1789694621930,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the initial world experience and mid\u2010term follow\u2010up of perimembranous ventricular septal defect (pmVSD) closure with a newly designed occluder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter closure of pmVSDs has been associated with a substantial risk of complete heart block, prompting many centers to abandon this intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective multicenter cohort study was conducted on patients with pmVSD undergoing catheter closure using the Amplatzer<jats:sup>\u00ae<\/jats:sup> Membranous VSD Occluder 2 in the initial 4 pilot centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients, median age 6 years (range 1.4\u201362 years), were enrolled and followed for 14\u2009\u00b1\u20093 months (range 8\u201320 months). The median weight was 26 kg (range 9.3\u201396 kg) and the mean Qp\/Qs ratio was 1.8\u2009\u00b1\u20090.7. The defect on left ventricular side measured 9.9\u2009\u00b1\u20093.5 mm and the orifice on right ventricular side was 8.1\u2009\u00b1\u20092.8 mm by echocardiography. Mean device size was 9.4\u2009\u00b1\u20092.4 mm (range 5\u201314 mm). An eccentric device was employed in 9 patients (47%) and a concentric device in 10 (53%). Overall, 18 patients (95%) had successful device implants. Procedural time was 122\u2009\u00b1\u200939 min. There were no procedural complications. Mild residual shunting was initially observed in 14 (78%) patients. At last follow\u2010up, mild residual shunting persisted in only 3 (17%) patients. There was no significant increase in aortic or tricuspid regurgitation. No patient had any degree of AV block, although one developed a transient left anterior fascicular block. Holter evaluation, obtained in all patients, was unremarkable in all.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This early cohort experience using a novel adapted transcatheter closure device for pmVSD suggests that the procedure is feasible, safe, and effective. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25004","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T12:52:59Z","timestamp":1369227179000},"page":"571-580","source":"Crossref","is-referenced-by-count":39,"title":["Transcatheter closure of perimembranous ventricular septal defect with the Amplatzer<sup>\u00ae<\/sup> membranous VSD occluder 2: Initial world experience and one\u2010year follow\u2010up"],"prefix":"10.1002","volume":"83","author":[{"given":"Apostolos","family":"Tzikas","sequence":"first","affiliation":[{"name":"Department of Cardiology Institut de Cardiologie de Montr\u00e9al, Universit\u00e9 de Montreal Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institut de Cardiologie de Montr\u00e9al, Universit\u00e9 de Montreal Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Velasco\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Cardiology H\u00f4pital Sainte\u2010Justine Universit\u00e9 de Montreal Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institut de Cardiologie de Montr\u00e9al, Universit\u00e9 de Montreal Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Alburquenque","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital de Ni\u00f1os Roberto del R\u00edo  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