{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:38:37Z","timestamp":1769017117024,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T00:00:00Z","timestamp":1383955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate the pathologic findings of the percutaneous Parachute device implanted in patients with severe heart failure (HF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently, most treatments of HF rest on optimal medical therapy with adjunctive interventional or surgical palliative treatments. One such treatment is the Parachute device, which partitions the left ventricle excluding the scarred myocardium from functioning myocardium, and has shown promise in clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have examined histopathologically seven cases [six males (age range 43\u201374 years; mean 56 years) and one female (55 years)] of Parachute device that were either retrieved at autopsy (<jats:italic>n<\/jats:italic>\u2009=\u20094) or during transplantation (<jats:italic>n<\/jats:italic>\u2009=\u20093); implant duration, 15\u20131,533 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients died of cardiac causes and none died from complications. Histologic early changes (&lt;30 days, <jats:italic>n<\/jats:italic>\u2009=\u20091) included adherent thrombus, with focal neutrophil infiltration and degenerating inflammatory cells. Over time (31\u2013300 days, <jats:italic>n<\/jats:italic>\u2009=\u20094), there was organized thrombus and development of neoendocardial thickening especially at the free\u2010edge of the device and its contact with the adjacent endocardium while the base of the device showed varying degrees of fibrin thrombus. The greatest organization of thrombus was observed in devices removed at &gt;300 days (680 and 1533 days); both had fractures of the foot along with strut fracture and one had tearing of the expanded polytetrafluoroethylene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The percutaneous Parachute device appears as a promising adjunctive treatment for patients suffering from severe HF. The pathologic changes are those of organizing thrombus with and without inflammation with minor complications of foot and strut fracture. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25010","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T15:46:49Z","timestamp":1369237609000},"page":"619-630","source":"Crossref","is-referenced-by-count":7,"title":["A pathologic study of explanted parachute devices from seven heart failure patients following percutaneous ventricular restoration"],"prefix":"10.1002","volume":"83","author":[{"given":"Elena","family":"Ladich","sequence":"first","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyuki","family":"Otsuka","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"e46","article-title":"Heart disease and stroke statistics\u20142010 update: A report from the American Heart Association","volume":"121","author":"Lloyd\u2010Jones D","year":"2010","journal-title":"Circulation"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91263-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1474"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.05.014"},{"key":"e_1_2_6_7_1","first-page":"125","article-title":"Left ventricular apex occluder. Description of a ventricular partitioning device","volume":"2","author":"Sharkey H","year":"2006","journal-title":"EuroIntervention"},{"key":"e_1_2_6_8_1","unstructured":"CostaM.Percutaneous ventricular restoration therapy (PVRT) in patients with ischemic dilated heart failure: 2\u2010Year clinical and echo outcomes of the first\u2010in\u2010human study of the Parachute left ventricle partitioning device. 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