{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:42:38Z","timestamp":1761561758827},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>We report the first case of mitral stenosis following Mitra\u2010Clip insertion in a patient with symptomatic NYHA IV heart failure, secondary to severe mitral regurgitation (MR). A 79\u2010year\u2010old female with a history of prior aortic valve replacement underwent percutaneous mitral valve (MV) repair. A single clip was advanced coaxially down onto the MV under TOE guidance, with the anterior and posterior leaflets clipped together between A2 and P2. TOE confirmed a significant reduction in MR (grade 4 to grade 1). Despite initial symptomatic relief, she represented 3 months later with similar symptoms. Repeat TOE confirmed a well positioned Mitra\u2010Clip with mild residual MR. However, the possibility of significant mitral stenosis was raised due to the presence of significant turbulence through the bi\u2010orifice valve, with a peak gradient of 25 mm Hg. In addition there was evidence of severe functional tricuspid valve (TV) regurgitation with elevated pulmonary artery pressures (PAP 90 mm Hg), confirmed on subsequent right heart catheterization. After repeated heart team discussions and a failure of optimal medical therapy, and despite a logistic EuroScore of 35.5, minimally invasive surgical replacement of the MV and simultaneous TV repair was undertaken via a right thoracotomy. Despite procedural success and initial good postoperative response, the patient died subsequently from a combination of hospital\u2010acquired pneumonia and significant gastrointestinal bleeding (post operative day 35). Mitra\u2010Clip is a promising novel approach to MV repair. The establishment of further clinical and echocardiographic based selection criteria will help identify the correct patients for this treatment. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.25011","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T15:58:42Z","timestamp":1369238322000},"page":"297-302","source":"Crossref","is-referenced-by-count":13,"title":["Development of mitral stenosis after single mitraclip insertion for severe mitral regurgitation"],"prefix":"10.1002","volume":"83","author":[{"given":"James","family":"Cockburn","sequence":"first","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals NHS Trust Brighton United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi","family":"Fragkou","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals NHS Trust Brighton United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hildick\u2010Smith","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals NHS Trust Brighton United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,10]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"14;1395","article-title":"On behalf of the EVEREST II Investigators. Percutaneous repair or surgery for mitral regurgitation","author":"Feldman T","year":"2011","journal-title":"N Engl J Med"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.08.063"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV4I4A76"},{"key":"e_1_2_5_6_1","unstructured":"Clinical Outcomes Assessment of the MitraClip Therapy Percutaneous Therapy for High Surgical Risk Patients (COAPT):ClinicalTrials.gov Sponsor: Evalve Collaborator: Abbott Vascular. Available at:http:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT01626079. Accessed on June 3 2013."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.702035"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.25011","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.25011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:43:57Z","timestamp":1696574637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.25011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,10]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/ccd.25011"],"URL":"https:\/\/doi.org\/10.1002\/ccd.25011","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,10]]}}}