{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:21:18Z","timestamp":1773832878341,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In patients undergoing primary percutaneous coronary interventions (PCI) for ST\u2010segment elevation myocardial infarction (STEMI), the occurrence of Contrast\u2010Induced Nephropathy (CIN) has a pronounced impact both on morbidity and mortality. We investigated the variables associated with CIN development in 481 consecutive patients with STEMI undergoing primary PCI and evaluated the predictive value of a 3\u2010variable clinical risk score (the AGEF score) based on age, left ventricular ejection fraction (EF), and estimated glomerular filtration rate (eGFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CIN was defined as an absolute increase in serum creatinine \u22650.5 mg\/dL or an increase \u226525% from baseline within 72 hr. AGEF score was calculated by adding 1 point to the Age\/EF(%) ratio if the eGFR was &lt;60 mL\/min per 1.73 m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the incidence of CIN was 5.2%. In\u2010hospital mortality was higher in patients with CIN than in those without (16% Vs 1.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). At multivariate analysis age (OR 1.06, <jats:italic>P<\/jats:italic>\u2009=\u20090.042), eGFR (OR 0.95, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), EF (OR 0.94, <jats:italic>P<\/jats:italic>\u2009=\u20090.007) and post\u2010procedural TIMI flow grade (OR 0.43, <jats:italic>P =<\/jats:italic> 0.045) were independent predictors of CIN. AGEF score was an accurate (OR 5.19, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, AUC 0.88) and calibrated (Hosmer\u2010Lemeshow <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200910.25, <jats:italic>P =<\/jats:italic> 0.25) predictor of CIN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Advanced age, depressed EF, and reduced eGFR are independent predictors of CIN development after primary PCI for STEMI. The preprocedural individual patient risk can be clinically assessed with the calculation of the AGEF score, which is based on such readily available parameters. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25023","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T15:58:37Z","timestamp":1369238317000},"page":"878-885","source":"Crossref","is-referenced-by-count":56,"title":["Age, glomerular filtration rate, ejection fraction, and the AGEF score predict contrast\u2010induced nephropathy in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention"],"prefix":"10.1002","volume":"82","author":[{"given":"Giuseppe","family":"And\u00f2","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Cardiology Section University of Messina and Azienda Ospedaliera Universitaria Policlinico \u201cGaetano Martino\u201d Messina  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