{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:16:06Z","timestamp":1696659366143},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare biodegradable polymer biolimus\u2010eluting (BES) with abluminal drug elution and durable polymer everolimus\u2010eluting (EES) stents in the treatment of bifurcation lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The persistence of a polymer in drug\u2010eluting stents (DES) following drug elution has been viewed as a possible culprit for restenosis. DES with biodegradable polymer may thus be associated with improved clinical outcomes, especially in high\u2010risk lesions such as those at bifurcation sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of consecutive de novo bifurcation lesions treated with EES between October 2006 and October 2011 and BES between February 2008 and March 2012. Study endpoints included major adverse cardiac events (MACE) defined as all\u2010cause death, myocardial infarction (MI), including peri\u2010procedural MI, and target vessel revascularization (TVR) as well as target lesion revascularization (TLR) separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 236 bifurcation lesions treated with either BES (79 lesions in 69 patients) or EES (157 lesions in 154 patients). Patient and procedural characteristics were broadly similar between the two groups. Estimated MACE and TVR rates at 2\u2010year follow\u2010up were similar between the BES and EES groups (MACE\u2009=\u200913.6\u2009\u00b1\u20094.6% vs. 14.6\u2009\u00b1\u20093.2% (<jats:italic>P<\/jats:italic>\u2009=\u20090.871); TVR\u2009=\u20096.9\u2009\u00b1\u20093.5% vs. 8.0\u2009\u00b1\u20092.7% (<jats:italic>P<\/jats:italic>\u2009=\u20090.889). No significant differences were noted between the two groups following propensity\u2010score matched analysis. There was no probable or definite stent thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BES use in the treatment of bifurcation lesions appears to be associated with good clinical outcomes, comparable to those seen with EES, at long\u2010term follow\u2010up. These results are hypothesis\u2010generating and need to be validated with larger studies. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25087","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T06:23:02Z","timestamp":1372314182000},"page":"889-895","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of abluminal biodegradable polymer biolimus\u2010eluting stents and durable polymer everolimus\u2010eluting stents in the treatment of coronary bifurcations"],"prefix":"10.1002","volume":"83","author":[{"given":"Charis","family":"Costopoulos","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit San Raffaele Scientific Institute Milan Italy"},{"name":"Interventional Cardiology Unit EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"Imperial College London London United 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