{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:44:47Z","timestamp":1762321487379,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T00:00:00Z","timestamp":1399075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess the association of kidney function with carotid artery revascularization outcomes in a large contemporary database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic kidney disease (CKD) is associated with increased mortality and adverse cardiovascular events after coronary intervention. There are limited data evaluating the association between CKD and adverse events among patients undergoing carotid artery revascularization procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Carotid Artery Revascularization and Endarterectomy (CARE) Registry<jats:sup>\u00ae<\/jats:sup> is a voluntary registry of 168 hospitals. Using data from the CARE Registry<jats:sup>\u00ae<\/jats:sup>, we examined registry patients undergoing carotid artery revascularization by either carotid endarterectomy (CEA) or carotid artery stenting (CAS) from May 2005 through March 2010. Patients were divided into four groups according to their glomerular filtration rate (GFR), as estimated by the Modification of Diet in Renal Disease Study Group equation using preprocedural serum creatinine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 11,832 patients who underwent carotid revascularization (6,899 CAS and 4,933 CEA). Patients with lower GFR were older, more frequently female, had more comorbidities, including hypertension, dyslipidemia, peripheral arterial disease, diabetes mellitus, chronic lung disease, ischemic heart disease, heart failure, and reduced left ventricular function, and were more likely to undergo CAS than CEA. In the overall population, CKD was associated with higher unadjusted in\u2010hospital and 30\u2010day rates of the combined endpoint of death, stroke, and myocardial infarction and the individual endpoint of stroke. After adjustment for baseline and preprocedural characteristics, CKD was not an independent predictor of adverse events in either CAS or CEA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with CKD have a greater number of comorbidities and worse unadjusted in\u2010hospital and 30\u2010day outcomes; CKD was not, however, an independent predictor of in\u2010hospital and 30\u2010day outcomes after carotid artery revascularization. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25101","type":"journal-article","created":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T07:22:40Z","timestamp":1372490560000},"page":"246-254","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Glomerular filtration rate on clinical outcomes after carotid artery revascularization in 11,832 patients from the CARE registry<sup>\u00ae<\/sup>"],"prefix":"10.1002","volume":"84","author":[{"given":"Luis","family":"Gruberg","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases Stony Brook University Medical Center Stony Brook New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Jeremias","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases Stony Brook University Medical Center Stony Brook New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Rundback","sequence":"additional","affiliation":[{"name":"Holy Name Hospital Teaneck New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Vernon","family":"Anderson","sequence":"additional","affiliation":[{"name":"Cardiology Division University of Texas Health Science Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and the University of Missouri \u2013 Kansas City Kansas City Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and the University of Missouri \u2013 Kansas City Kansas City Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Rosenfield","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Medicine Massachusetts General Hospital Boston 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