{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:01:09Z","timestamp":1773270069706,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T00:00:00Z","timestamp":1377907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed the long\u2010term outcomes of elderly patients who had in\u2010stent restenosis (ISR) treated with drug\u2010eluting stents (DES) compared with other treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Elderly patients with ISR represent a vulnerable group of which little is known regarding the safety and efficacy of repeat percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed patients \u226565 years of age who underwent PCI for ISR in the National Cardiovascular Data Registry<jats:sup>\u00ae<\/jats:sup> from 2004 to 2008. Death, myocardial infarction (MI), revascularization, stroke, and bleeding were assessed for up to 30 months by a linkage with Medicare rehospitalization claims.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 43,679 linked patients, 30,012 were treated with DES, 8,277 with balloon angioplasty (BA), and 4,917 with bare metal stents (BMS). Compared with BMS, DES use was associated with a lower propensity score\u2010matched (PM) risk of death (hazard ratio [HR] 0.72; 95% confidence interval [CI] 0.66\u20130.80, <jats:italic>P<\/jats:italic> &lt; 0.001), MI (HR 0.81; 95% CI 0.70\u20130.93, <jats:italic>P<\/jats:italic> = 0.003), and revascularization (HR 0.90; 95% CI 0.82\u20131.00, <jats:italic>P<\/jats:italic> = 0.055). Compared with BA, DES use was associated with a lower PM risk of death (HR 0.82; 95% CI 0.76\u20130.89, <jats:italic>P<\/jats:italic> &lt; 0.001) and revascularization (HR 0.86; 95% CI 0.80\u20100.93, <jats:italic>P<\/jats:italic> &lt; 0.001), but no statistically significant difference across other endpoints. There were no significant differences in long\u2010term outcomes for BA compared with BMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was lower mortality and reduced risk for MI, revascularization, and stroke, but a similar rate of bleeding with DES compared with other modalities. Our results indicate that DES use is a comparatively effective strategy to treat elderly patients with ISR. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25108","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T11:37:50Z","timestamp":1372851470000},"page":"171-181","source":"Crossref","is-referenced-by-count":4,"title":["Comparative effectiveness of drug\u2010eluting stents on long\u2010term outcomes in elderly patients treated for in\u2010stent restenosis: A report from the National Cardiovascular Data Registry"],"prefix":"10.1002","volume":"83","author":[{"given":"Michael A.","family":"Kutcher","sequence":"first","affiliation":[{"name":"Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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