{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:27:29Z","timestamp":1761863249414},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To obtain imaging evidence by 2\u2010week optical coherence tomography (OCT) on the completion of neointimal coverage (NIC; the percentage of stent strut coverage and thickness of the formed neointima) completion after implantation of the Endeavor zotarolimus\u2010eluting stent (E\u2010ZES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the fact that NIC is a cardinal process in the pathomechanism of late stent thrombosis, little imaging information is available on morphological changes thereof on a short\u2010time interval basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>27 Japanese patients with stable angina pectoris and de novo native coronary artery lesions were enrolled, and 27 lesions (30 implantations) were examined. OCT was performed at weeks 2, 4, 6, 8, and 10 after E\u2010ZES implantation. NIC was examined using cross\u2010sectional OCT images obtained at the 1.0\u2010mm intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 621 cross\u2010sectional OCT images, which depicted 7,747 stent struts, were analyzed. The mean percentages of stent strut coverage at weeks 2, 4, 6, 8, and 10 after E\u2010ZES implantation were 12.3, 70.4, 67.9, 86.0, and 99.2%, respectively; a marked increase was found between weeks 2 and 4. The mean thicknesses of the formed neointima were 40.2, 52.1, 48.1, 86.5, and 146.2 \u03bcm at respective weeks, with the high\u2010signal and thick neointima (146 \u00b5m) at week 10. An intracoronary thrombus was detected in only one stent at week 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The full circumferential coverage of the vessel wall by the high\u2010signal neointima was found at as early as week 10 after E\u2010ZES implantation, imparting a surrogate index for vascular healing by NIC. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25136","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T15:13:04Z","timestamp":1374246784000},"source":"Crossref","is-referenced-by-count":8,"title":["Two\u2010week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus\u2010eluting stent"],"prefix":"10.1002","volume":"82","author":[{"given":"Makoto","family":"Nishinari","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Angiology Kitasato University School of Medicine Kanagawa 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