{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:48:41Z","timestamp":1768780121031,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the safety and effectiveness of performing percutaneous coronary intervention (PCI) before transcatheter aortic valve implantation (TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The presence of coronary artery disease (CAD) negatively impact procedural outcomes and long\u2010term survival after (TAVI). The management of obstructive CAD before TAVI is not yet well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with severe symptomatic aortic stenosis (AS) (<jats:italic>n<\/jats:italic>\u2009=\u2009249) that underwent TAVI were divided into two groups: patients with CAD (subdivided to patients treated with TAVI alone and to patients that underwent PCI before TAVI) and patients with isolated AS. Procedural endpoints, device success and adverse events were considered according to the Valve Academic Research Consortium (VARC) definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a cohort of 249 consecutive patients with mean age of 83.2\u2009\u00b1\u20095.5 years, 83 patients with AS\u2009+\u2009CAD were treated with TAVI alone, 61 patients with AS\u2009+\u2009CAD underwent PCI before TAVI and 105 patients underwent TAVI for isolated AS. The mean duration of follow\u2010up was 17 months (range: 6\u201336 months). Despite a significantly higher logistic EuroScore of the AS+CAD group compared to the AS alone group (30.1 vs. 21.1 <jats:italic>P<\/jats:italic>\u2009&lt;\u20090. 001), the overall VARC\u2010adjudicated endpoints did not differ between the groups. All\u2010cause mortality at 30\u2010days was 1.6% for patients with AS+CAD treated with PCI compared to 2.9% for patients with AS alone (<jats:italic>P<\/jats:italic>\u2009=\u20091).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Performing PCI before TAVI in high\u2010risk elderly patients with significant CAD and severe AS is feasible and safe. This combined treatment approach did not increase the periprocedural risk for complications or the all\u2010cause mortality. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25233","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T10:58:32Z","timestamp":1383217112000},"page":"649-654","source":"Crossref","is-referenced-by-count":45,"title":["Comparison of early and late outcomes of TAVI alone compared to TAVI plus PCI in aortic stenosis patients with and without coronary artery disease"],"prefix":"10.1002","volume":"83","author":[{"given":"Yigal","family":"Abramowitz","sequence":"first","affiliation":[{"name":"Department of Cardiology The Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Steinvil","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Arbel","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine 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