{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:25:11Z","timestamp":1767651911274},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Objectives: This INDOLIMUS Registry sought to evaluate the safety and efficacy of the biodegradable polymer coated Indolimus<jats:sup>\u00ae<\/jats:sup> sirolimus\u2010eluting coronary stent for the treatment of coronary artery disease across a wide range of patients treated in routine clinical practice, including those with high\u2010risk characteristics and complex lesions. Background: First\u2010generation drug\u2010eluting stents utilize nonbiodegradable polymeric coatings, whose persistent presence in the arterial wall may negatively affect long\u2010term outcomes. It has been hypothesized that persistent presence of polymer may compromise the safety of drug\u2010eluting stents, and that therefore biodegradable polymer coatings might reduce late adverse events in an unselected patient population. Methods: All 530 consecutive unselected patients (415 males and 115 females) included who underwent percutaneous coronary intervention at the Sri Venkateswara Institute of Medical Sciences, Tirupati, India between August 2012 and March 2013, with an in\u2010hospital, at 30\u2010days and at 6\u2010months follow\u2010up. Retrospective analysis of those data had been done. Results: A total of 617 lesions were treated in 530 enrolled patients (mean age 54.9\u2009\u00b1\u200910.8 years) with average stent length of 18.8\u2009\u00b1\u20096.0 mm. An average of 1.18 stents was implanted per patient. The patients' characteristics are noted as having 169 (31.9%) patients of diabetics and 215 (40.6%) hypertension. Smoking, alcoholism and tobacco chewing were found in 273 (51.5%), 130 (24.5%) and 17 (3.2%), respectively. The indications for intervention were unstable angina in 77 (14.5%) and previous myocardial infarction in 56 (10.6%) of the patients. Lesions were of type B2 in 264 (42.7%) and type C in 127 (20.6%). Stent delivery was successful in all cases and in\u2010hospital, 30\u2010days and 6\u2010months follow\u2010up of all 530 patients was obtained. The incidence of any major adverse cardiac events at in\u2010hospital, at 30\u2010days and at 6\u2010months were 5 (0.94%), 8 (1.52%), and 18 (3.40%), respectively. Long term follow\u2010up of this registry is ongoing to confirm safety and efficacy profiles. Conclusions: The relatively low event rate that was observed in INDOLIMUS Registry indicates that the biodegradable polymer coated Indolimus<jats:sup>\u00ae<\/jats:sup> sirolimus\u2010eluting coronary stent can achieve excellent clinical performances in a large group of patients. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.25246","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T17:26:41Z","timestamp":1381858001000},"source":"Crossref","is-referenced-by-count":3,"title":["The real world experience of the biodegradable polymer\u2010coated sirolimus\u2010eluting coronary stent system"],"prefix":"10.1002","volume":"88","author":[{"given":"D.","family":"Rajasekhar","sequence":"first","affiliation":[{"name":"Department of Cardiology Sri Venkateswara Institute of Medical Sciences (SVIMS) Tirupati Andhra Pradesh 517507 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