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Background: Previous research has demonstrated the cost\u2010effectiveness of pVAD hemodynamic support for patients undergoing high\u2010risk percutaneous coronary intervention. For patients in cardiogenic shock (CS), use of pVAD therapy has been shown to reduce length of stay (LOS). Methods: National utilization and outcome data from the 2010\u20132011 MedPAR and state\u2010sponsored all\u2010payer databases were collected for patients with an acute myocardial infarction complicated by CS who were treated with either a pVAD (<jats:italic>n<\/jats:italic>\u2009=\u2009883) or with traditional surgical hemodynamic support alternatives (ECMO and extracorporeal VAD) (<jats:italic>n<\/jats:italic>\u2009=\u2009305). Results: Discharge survival was greater with pVADs than with surgical alternatives (56% vs. 42%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and was achieved with a strong trend toward reduced LOS (13.2 and 17.9 days, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.055) and a significantly lower cost of the index admission ($90,929 and $144,257, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Cost\u2010effectiveness analysis based on the national data demonstrated that pVAD achieved improved outcomes at lower cost. Data were also collected for similar patients who underwent protocol\u2010guided pVAD therapy (using Impella 2.5) at PinnacleHealth, between 2009 and 2011 (<jats:italic>n<\/jats:italic>\u2009=\u200930). At this site, the survival rate increased to 60%, length of hospitalization was shortened to 6 days, and admission costs were lowered to $53,850 relative to the surgical alternatives strategy. Conclusions: For patients in CS requiring emergent hemodynamic support, pVAD therapy offers a less invasive alternative that can be deployed sooner, resulting in better outcomes, shorter LOS, lower costs and with no incremental cost, and a survival benefit when compared with traditional surgical hemodynamic support alternatives. PVAD therapy (and Impella 2.5 in particular) is emerging as a dominant strategy for this challenging patient population. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.25247","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T16:50:35Z","timestamp":1381855835000},"source":"Crossref","is-referenced-by-count":28,"title":["Percutaneous cardiac assist devices compared with surgical hemodynamic support alternatives"],"prefix":"10.1002","volume":"83","author":[{"given":"Brijeshwar","family":"Maini","sequence":"first","affiliation":[{"name":"PinnacleHealth Harrisburg Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gregory","sequence":"additional","affiliation":[{"name":"Presscott Associates\u2014A Division of ParenteBeard LLC Avon Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis J.","family":"Scotti","sequence":"additional","affiliation":[{"name":"Fairleigh Dickinson University Teaneck New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Buyantseva","sequence":"additional","affiliation":[{"name":"PinnacleHealth Harrisburg Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.03.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I4A72"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.814947"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00429-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00879-2"},{"key":"e_1_2_7_7_1","first-page":"e2","article-title":"American Heart Association Statistics Committee and Stroke Statistics Subcommittee. 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