{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:21:53Z","timestamp":1761765713543},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T00:00:00Z","timestamp":1383955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare optical coherence tomography (OCT)\u2010derived plaque characteristics of coronary target lesions between diabetic patients with acute coronary syndrome (ACS) versus stable angina pectoris (SAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In vivo assessment of plaque composition of coronary culprit lesions in a cardiovascular high\u2010risk population with diabetes mellitus is incompletely elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>102 diabetic patients with coronary de novo lesions were enrolled and categorized into an ACS\u2010group (40 patients) and a SAP\u2010group (62 patients) according to their clinical presentation. Assessment of clinical data, angiographic, and OCT imaging including the analysis of plaque composition and lipid content of the target lesions were performed prior to percutaneous coronary intervention and compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plaque characteristics of patients in the ACS\u2010group compared with the SAP\u2010group showed a higher incidence of lipid\u2010rich plaque [33 (82.5%) vs. 25 (40.3%)], thin\u2010capped fibroatheroma [29 (72.5%) vs. 10 (16.1%)], macrophage infiltration [32 (80.0%) vs. 21 (33.9%)], thrombus [23 (57.5%) vs. 2 (3.2%)], and plaque rupture [27 (67.5%) vs. 2 (3.2%)] (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Moreover, there was a wider lipid arc (174.5\u2009\u00b1\u200933.8\u00b0 vs. 122.9\u2009\u00b1\u200943.9\u00b0), a longer lipid plaque length (6.52\u2009\u00b1\u20092.04 mm vs. 3.73\u2009\u00b1\u20092.16 mm), a greater lipid volume index (1117.2\u2009\u00b1\u2009349.9 vs. 504.8\u2009\u00b1\u2009379.3), and a smaller minimal fibrous cap thickness (51.52\u2009\u00b1\u20099.14 \u00b5m vs. 80.33\u2009\u00b1\u200926.71 \u00b5m) within lipid\u2010rich lesions of ACS patients (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diabetic patients with ACS exhibit more vulnerable plaque features in coronary culprit lesions compared with diabetic patients with SAP. This may provide rationale for a specific therapeutic strategy either by pharmacological plaque stabilization or coronary intervention in any lesion with vulnerable plaque morphology in patients with diabetes. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25267","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T04:35:22Z","timestamp":1382589322000},"page":"700-707","source":"Crossref","is-referenced-by-count":19,"title":["Optical coherence tomography derived differences of plaque characteristics in coronary culprit lesions between type 2 diabetic patients with and without acute coronary syndrome"],"prefix":"10.1002","volume":"84","author":[{"given":"Sebastian","family":"Reith","sequence":"first","affiliation":[{"name":"Department of Cardiology Medical Clinic I, University Hospital of the RWTH Aachen  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