{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:07:37Z","timestamp":1788480457217,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Previous studies reported that integrated backscatter intravascular ultrasound (IB\u2010IVUS) provides high diagnostic accuracy for tissue characterization of coronary plaques and that pregnancy\u2010associated plasma protein A (PAPP\u2010A) could be a marker of adverse cardiac outcome in patients with cardiovascular disease. We examined whether IB\u2010IVUS and PAPP\u2010A levels could predict the incidence of no\u2010reflow during percutaneous coronary intervention (PCI)<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>About 176 consecutive patients (138 men, mean age 68\u2009\u00b1\u200911 years) who underwent PCI with IB\u2010IVUS were prospectively enrolled. Combined no\u2010reflow, including transient filter no\u2010reflow by using distal protection devices, was observed in 31 patients. The percentages of coronary lipid volume (%LV) analyzed by IB\u2010IVUS and serum PAPP\u2010A were significantly higher in patients with combined no\u2010reflow than normal\u2010reflow. To predict no\u2010reflow, a receiver operating characteristic (ROC) analysis determined cut\u2010off values of %LV as 62% and serum PAPP\u2010A as 7.71 ng\/mL. The multivariate logistic regression analysis showed that %LV (hazard ratio 4.5, 95% confidence interval 1.6\u201313.4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and PAPP\u2010A (hazard ratio 4.32, 95% confidence interval 1.5\u201312.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) were independent predictors of combined no\u2010reflow<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>%LV analyzed by IB\u2010IVUS and serum PAPP\u2010A levels were closely associated with the coronary no\u2010reflow phenomenon. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25294","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T02:52:41Z","timestamp":1384397561000},"page":"43-50","source":"Crossref","is-referenced-by-count":7,"title":["A combination of plaque components analyzed by integrated backscatter intravascular ultrasound and serum pregnancy\u2010associated plasma protein a levels predict the no\u2010reflow phenomenon during percutaneous coronary intervention"],"prefix":"10.1002","volume":"85","author":[{"given":"Hyuma","family":"Daidoji","sequence":"first","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Otaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harutoshi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Arimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Shishido","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Nephrology Yamagata University School of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.054"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.896225"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.01.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.135822"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-07-0936"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.061"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90553-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003147"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.10.025"},{"key":"e_1_2_7_12_1","first-page":"545","article-title":"Investigators. 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