{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:27:45Z","timestamp":1761863265192},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is accumulating evidence that up to 20% of the implanted devices after TAVI are associated with a significant degree of paravalvular leaks, which appear to be associated with a negative clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 355 patients with severe aortic valvular stenosis (AVS) were treated by TAVI (Corevalve <jats:italic>n<\/jats:italic>\u2009=\u2009222, Edwards Sapien <jats:italic>n<\/jats:italic>\u2009=\u2009133). Survival, NT\u2010proBNP and the grade of PVL were quantified up to 12 months after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Technical success rate was 97.8%. Thirty\u2010day mortality was 9.6%. Post\u2010procedural transvalvular aortic regurgitation was seen only in a minority of cases (5%), whereas PVL were frequently observed (grade: &lt;1+ in 58.2%, \u22651\u2013&lt;2 in 33.9%, and \u22652 in 7.9%). There was a clear relation\u2010ship between PVL and adverse outcome (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). After a transient increase, NT\u2010proBNP showed a significant decline. Interestingly, a PVL \u22652+ was associated with a much higher rise in NT\u2010proBNP compared to the other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and a post\u2010procedural increase in NT\u2010proBNP by more than 1640 ng L<jats:sup>\u22121<\/jats:sup> within 5 days was associated with a significant increase in rate of death (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TAVI is an efficient treatment option for high\u2010risk patients with severe AVS. The incidence of PVL is an inacceptable clinical problem. Serial measurement of NT\u2010proBNP can be used for risk\u2010stratification in patients with a significant PVL. In general, PVL graded \u22652+ is associated with a dramatically increased 6\u2010month mortality. Therefore, any action to reduce paraprosthetical regurgitation is highly recommended. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25295","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T08:28:50Z","timestamp":1385022530000},"page":"502-514","source":"Crossref","is-referenced-by-count":21,"title":["Clinical impact of paravalvular leaks on biomarkers and survival after transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"85","author":[{"given":"Dimitry","family":"Schewel","sequence":"first","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jury","family":"Schewel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wohlmuth","sequence":"additional","affiliation":[{"name":"ASKLEPIOS Proresearch Clinical Research and Development Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Meincke","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Thielsen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Kreidel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asklepios Clinics St. Georg Hospital Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01670-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.049"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.639450"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.677237"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.047"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698258"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV4I3A63"},{"key":"e_1_2_6_10_1","first-page":"899","article-title":"Aortic regurgitation after transcatheter aortic valve implantation: Incidence and early outcome","volume":"97","author":"Abdel\u2010Wahab M","year":"2011","journal-title":"Results from the German transcatheter aortic valve interventions registry. 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