{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:44:46Z","timestamp":1783442686817,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AngioScore, Inc., Fremont, CA, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p><jats:styled-content>Objective:<\/jats:styled-content> Scoring balloons are particularly useful in the acute treatment of fibro\u2010calcific, bifurcation and in\u2010stent restenosis lesions but have not been shown to affect the restenosis rate. Conventional balloons coated with paclitaxel have recently been shown to reduce restenosis rates in certain lesion subsets, but are associated with suboptimal acute results. A novel paclitaxel\u2010coated scoring balloon was developed to overcome these limitations. <jats:bold><jats:styled-content>Design:<\/jats:styled-content><\/jats:bold> AngioSculpt<jats:sup>\u00ae<\/jats:sup> scoring balloons (SB) were coated with paclitaxel admixed with a specific excipient. <jats:bold><jats:styled-content>Setting and Interventions:<\/jats:styled-content><\/jats:bold> Four <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies were performed: (a) loss of the drug during passage to the lesion, (b) transfer of the drug to the vessel wall; (c) inhibition of neo\u2010intimal proliferation in porcine coronary arteries as compared to uncoated SB and the Paccocath\u2122, and (d) evaluation of the dose\u2010response to 1.5\u201312 \u03bcg of paclitaxel\/mm<jats:sup>2<\/jats:sup>. <jats:bold><jats:styled-content>Main outcome measures and Results:<\/jats:styled-content><\/jats:bold> Drug loss during delivery to the lesion was 17%\u2009\u00b1\u20098%, and transfer to the vessel wall was 9%\u2009\u00b1\u20094% of dose on unused balloons. The paclitaxel\u2010coated SB resulted in a lower late lumen loss of 0.27\u2009\u00b1\u20090.24 mm compared to 1.4\u2009\u00b1\u20090.7 mm with the uncoated SB (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Histomorphometry revealed larger luminal areas of 6.8\u2009\u00b1\u20091.6 mm<jats:sup>2<\/jats:sup> (paclitaxel\u2010coated SB) and 5.8\u2009\u00b1\u20091.7 mm<jats:sup>2<\/jats:sup> (Paccocath) as compared to the uncoated SB (2.3\u2009\u00b1\u20091.5 mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). No coating related adverse effects were observed on follow\u2010up angiography or histologic examination at the treatment site or downstream myocardium. <jats:bold><jats:styled-content>Conclusion:<\/jats:styled-content><\/jats:bold> A novel paclitaxel\u2010coated SB leads to a significant inhibition of neointimal proliferation in the porcine coronary model. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.25296","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T07:54:47Z","timestamp":1385020487000},"page":"1089-1098","source":"Crossref","is-referenced-by-count":18,"title":["Inhibition of neo\u2010intimal hyperplasia in porcine coronary arteries utilizing a novel paclitaxel\u2010coated scoring balloon catheter"],"prefix":"10.1002","volume":"84","author":[{"given":"Bodo","family":"Cremers","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III University of Saarland Homburg\/Saar 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