{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T09:31:44Z","timestamp":1705224704349},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare a new stent with an asymmetric coating, eluting the drug to the abluminal surface, to a stent with a conventional coating eluting the drug both to the luminal and the abluminal side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Stents with asymmetric coating, eluting the drug to the vessel wall (BPSES\u2010A), could potentially give faster reendothelialization after percutaneous coronary interventions (PCI) and decrease in in\u2010stent thrombosis and late restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BPSES\u2010A, conventional coated stents (BPSES\u2010C), biodegradable polymer stents without drug (BPS, for control), and bare metal stents (BMS, for control) were implanted into the coronary arteries of 38 pigs (75 stents). Pigs were sacrificed after 4, 12, and 24 weeks. Quantitative coronary angiography was used to compare in\u2010stent late lumen loss (LLL) and electron microscopy was used to reveal levels of reendothelialization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The stents were all successfully implanted. LLL of BPSES\u2010A, BPSES\u2010C, BMS, and BPS were 0.56\u2009\u00b1\u20090.51, 0.60\u2009\u00b1\u20090.58, 0.89\u2009\u00b1\u20090.43, and 1.68\u2009\u00b1\u20090.30 mm, respectively, after 4 weeks. LLL of BPSES\u2010A and BPSES\u2010C were 0.63\u2009\u00b1\u20090.53 and 0.69\u2009\u00b1\u20090.24 mm, respectively, after 12 weeks. LLL of BPSES\u2010A, BPSES\u2010C, and BMS were 0.42\u2009\u00b1\u20090.15 m, 0.56\u2009\u00b1\u20090.28 mm, and 0.99\u2009\u00b1\u20090.13 mm, respectively, after 24 weeks. The scaling of reendothelialization was as follows: after 4 weeks BMS\u2009&gt;\u2009= BPS\u2009&gt;\u2009BPSES\u2010A\u2009&gt;\u2009BPSES\u2010C, after 12 weeks BPSES\u2010A\u2009&gt;\u2009BPSES\u2010C, and after 24 weeks BMS\u2009&gt;\u2009BPSES\u2010A\u2009&gt;\u2009BPSES\u2010C. Reendothelialization was better in BPSES\u2010A than BPSES\u2010C (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There was no correlation between LLL and reendothelialization (<jats:italic>P<\/jats:italic>\u2009=\u20090.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asymmetric coating of coronary stents might be helpful to improve reendothelialization. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25335","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T06:37:13Z","timestamp":1386657433000},"source":"Crossref","is-referenced-by-count":9,"title":["Solely abluminal drug release from coronary stents could possibly improve reendothelialization"],"prefix":"10.1002","volume":"88","author":[{"given":"Haijun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University Aalborg \u00d8 Denmark"},{"name":"Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Public Health Safety Ministry of Education, School of Public Health, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University Aalborg \u00d8 Denmark"},{"name":"Institute of Chemistry Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egon","family":"Toft","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University Aalborg \u00d8 Denmark"},{"name":"Biomedical Research Center College of Medicine, Qatar University Shareh Jamiaa Postbox 2716, Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_2_6_4_1","first-page":"1440","article-title":"Stent thrombosis late after implantation of first\u2010generation drug\u2010eluting stents: Cause for concern","volume":"115","author":"Camendiz E","year":"2007","journal-title":"Circulation"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60314-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.3.6.731"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/ica.11.91"},{"key":"e_1_2_6_8_1","first-page":"488","article-title":"Very late drug\u2010eluting stent thrombosis related to incomplete stent endothelialization: In\u2010vivo demonstration by optical coherence tomography","volume":"21","author":"Santiago JV","year":"2009","journal-title":"J Inv Cardiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675934"},{"key":"e_1_2_6_13_1","first-page":"883","article-title":"Five\u2010year clinical outcomes of a polymer\u2010free sirolimus\u2010eluting stent versus a permanent polymer paclitaxel\u2010eluting stent: Final results of the intracoronary stenting and angiographic restenosis \u2010 test equivalence between two drug\u2010eluting stents (ISAR\u2010TEST) trial. 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