{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:45:20Z","timestamp":1778125520644,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of female sex on mortality after transcatheter aortic valve implantation (TAVI) is controversial. Post\u2010procedural aortic regurgitation (AR)\u2009\u2265\u20092 has been associated with poor outcomes. Whether sex differences in post\u2010procedural AR\u2009\u2265\u20092 could contribute to a mortality difference between women and men is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred fifty\u2010six patients, women (53.1%), men (46.9%), with aortic stenosis underwent TAVI with the CoreValve system (92.8%) or the Edwards SAPIEN valve system (7.2%). AR was graded semiquantitatively as 0\u2009=\u2009none, 1\u2009=\u2009trivial, 2\u2009=\u2009mild, 3\u2009=\u2009moderate, and 4\u2009=\u2009severe. The incidence of post\u2010procedural AR\u2009\u2265\u20092 was reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Procedural success was similar in women as compared to men (97.9 vs 96.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.32). Post\u2010procedural AR\u2009\u2265\u20092 occurred less frequently in women than in men (20.9 vs 29.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). After a median follow\u2010up of 434 days, all\u2010cause mortality tended to be lower in women than in men (20.7 vs 26.6%, logrank <jats:italic>P<\/jats:italic>\u2009=\u20090.10), and was significantly higher in patients with AR\u2009\u2265\u20092 than in those without (34.8 vs 19.7%, logrank <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). AR\u2009\u2265\u20092 [hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.22\u20132.43, <jats:italic>P<\/jats:italic>\u2009=\u20090.002], but not female sex (<jats:italic>P<\/jats:italic>\u2009=\u20090.17) was an independent predictor of all\u2010cause death at multivariable Cox regression. The predictive value of AR\u2009\u2265\u20092 was restricted to men (HR 2.96, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 among men; HR 0.86, <jats:italic>P<\/jats:italic>\u2009=\u20090.60 among women; <jats:italic>P<\/jats:italic> for interaction\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women, as compared to men, present a trend toward lower mortality. A significant lower incidence of post\u2010procedural AR\u2009\u2265\u20092 among women contributes to this finding. Female sex, however, was not a significant independent predictor of death. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25377","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T20:12:24Z","timestamp":1389298344000},"page":"264-271","source":"Crossref","is-referenced-by-count":24,"title":["Sex differences in postprocedural aortic regurgitation and mid\u2010term mortality after transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"84","author":[{"given":"Giuseppe","family":"Ferrante","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Istituto Clinico Humanitas IRCCS Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pagnotta","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Istituto Clinico Humanitas IRCCS Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Sonia","family":"Petronio","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Istituto Clinico S. Ambrogio, IRCCS San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedy","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Istituto Clinico S. Ambrogio, IRCCS San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fiorina","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Spedali Civili di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Giannini","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mennuni","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Istituto Clinico Humanitas IRCCS Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Niguarda Ca' Granda Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Klugmann","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Niguarda Ca' Granda Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Ettori","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Spedali Civili di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Presbitero","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Istituto Clinico Humanitas IRCCS Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202277"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114705"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.050"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.877"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I5A91"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.08.051"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.217158"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.09.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.07.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.047"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.047"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.048"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.03.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.11.091"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.035"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.25377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.25377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:51:34Z","timestamp":1696575094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.25377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/ccd.25377"],"URL":"https:\/\/doi.org\/10.1002\/ccd.25377","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}