{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:41:17Z","timestamp":1787733677918,"version":"build-2784847793"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T00:00:00Z","timestamp":1404432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RA969\/7-2"],"award-info":[{"award-number":["RA969\/7-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the safety and efficacy of deep sedation (DS) as compared to general anaesthesia (GA) in percutaneous mitral valve repair (PMVR) using the MitraClip\u00ae system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PMVR with the MitraClip\u00ae system has emerged as a therapeutic alternative to surgical valve repair in high\u2010risk patients. The PMVR procedure is typically performed under GA. Due to their high surgical risk, avoidance of GA in many of those patients would be desirable. <jats:italic>Methods<\/jats:italic><jats:bold>:<\/jats:bold> In an open\u2010label observational study 21 patients with severe mitral regurgitation were randomized to either GA or DS using propofol. Primary endpoints of this comparison were related to safety with rate of conversion from DS to GA, bleeding, aspiration, and pneumonia. Secondary endpoints were related to efficacy with procedural, in\u2010hospital, and mid\u2010term outcome at 1 month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All clips have been implanted successfully in both groups. No conversion from DS to GA was necessary. Four patients undergoing GA suffered from upper respiratory tract infections and two from peripheral vascular complications during placement of central venous catheter for GA. Short\u2010 and mid\u2010term efficacy were comparable in both groups with a reduced hospital stay in the DS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PVMR in high\u2010risk patients performed under DS is as safe and effective as with GA, preventing complications related to GA and shortening hospital stay. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25570","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T17:48:39Z","timestamp":1402076919000},"source":"Crossref","is-referenced-by-count":24,"title":["Safety and efficacy of deep sedation as compared to general anaesthesia in percutaneous mitral valve repair using the MitraClip\u00ae system"],"prefix":"10.1002","volume":"84","author":[{"given":"Tienush","family":"Rassaf","sequence":"first","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Balzer","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Zeus","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Rammos","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Shayganfar","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke V.","family":"Hall","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Wagstaff","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[{"name":"Medical Faculty Department of Medicine Division of Cardiology Pulmonology and Vascular Medicine University Hospital D\u00fcsseldorf Moorenstra\u00dfe 5 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.225789"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03301-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2003.12.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.065"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.077"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.067"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22415"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I5A90"}],"container-title":["Catheterization and Cardiovascular 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