{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:28:51Z","timestamp":1791232131325,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Contrast\u2010induced acute kidney injury (CI\u2010AKI) may occur after percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated patients with ST\u2010elevation myocardial infarction (STEMI) undergoing emergency PCI with serial biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 390 patients enrolled in the HORIZONS\u2010AMI biomarker substudy, 56 (14.3%) developed AKI. In the AKI group, the levels of B\u2010type natriuretic peptide were consistently higher than in the no\u2010AKI group at baseline (<jats:italic>P<\/jats:italic>\u2009=\u20090.0327), hospital discharge (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002), 30\u2010day follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u20090.0193), and 1\u2010year follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u20090.031). At hospital discharge, the AKI group had elevated biomarkers compared to the no\u2010AKI group: <jats:sc>D<\/jats:sc>\u2010dimer (<jats:italic>P<\/jats:italic>\u2009=\u20090.0066), C\u2010reactive protein (<jats:italic>P<\/jats:italic>\u2009=\u20090.0468), endothelial cell\u2010selective adhesion molecule (<jats:italic>P<\/jats:italic>\u2009=\u20090.0169), adiponectin (<jats:italic>P<\/jats:italic>\u2009=\u20090.0346), and von Willebrand factor (<jats:italic>P<\/jats:italic>\u2009=\u20090.0168); there was also a trend toward higher cystatin C (<jats:italic>P<\/jats:italic>\u2009=\u20090.0585) in the AKI group. Similar correlations between biomarker panel increase and the development of CI\u2010AKI were consistent at baseline, 30\u2010day, and 1\u2010year follow\u2010up. Chemokine (C\u2010C motif) ligand 23 showed an opposite pattern with an increase at all time points in the no\u2010AKI compared to the AKI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of CI\u2010AKI after primary PCI for STEMI may be associated with hemostatic imbalances, activation of procoagulants, decreased endogenous anticoagulants, enhanced inflammation, platelet activation, or decreased fibrinolytic activity. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25620","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T09:21:18Z","timestamp":1406712078000},"page":"335-342","source":"Crossref","is-referenced-by-count":22,"title":["Analysis of biomarkers for risk of acute kidney injury after primary angioplasty for acute ST\u2010segment elevation myocardial infarction: Results of the <scp>HORIZONS\u2010AMI<\/scp> trial"],"prefix":"10.1002","volume":"85","author":[{"given":"Alejandra","family":"Guerchicoff","sequence":"first","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"},{"name":"Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"},{"name":"Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New 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