{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:06:27Z","timestamp":1780499187191,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the clinical outcomes following unprotected left main coronary artery (ULMCA) percutaneous coronary intervention (PCI) of ostial\/midshaft lesions between first and new generation drug\u2010eluting stents (DES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical outcomes after treatment of ostial\/midshaft lesions in ULMCA with first generation DES were favorable. However, to date, data regarding treatment for those lesion subsets with new generation DES have not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 219 patients with ostial\/midshaft lesions in ULMCA treated with first (<jats:italic>n<\/jats:italic>\u2009=\u2009139) or new generation DES (<jats:italic>n<\/jats:italic>\u2009=\u200980) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a higher prevalence of IVUS use (35.2% vs. 50.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.032) and postdilation (70.5% vs. 93.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with larger maximum balloon diameter (3.81\u2009\u00b1\u20090.45 vs. 4.08\u2009\u00b1\u20090.44, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the new generation DES group. At a median follow\u2010up period of 730 days, there were no significant differences in the propensity\u2010score adjusted analyses, for major adverse cardiac events (MACE) defined as composite endpoint of all\u2010cause death, myocardial infarction, and target vessel revascularization (hazard ratio (HR) [new vs. first generation DES]: 1.22; 95% confidence interval (CI): 0.64\u20132.31; <jats:italic>P<\/jats:italic>\u2009=\u20090.549). Of note, target lesion revascularization rates at 2\u2010years were only 0.9% and 2.7%, for first and new generation DES groups, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.339). On multivariable analysis, SYNTAX score (HR: 1.06; 95% CI: 1.02\u20131.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.006) and European System for Cardiac Operative Risk Evaluation (HR: 1.14; 95% CI: 1.00\u20131.31, <jats:italic>P<\/jats:italic>\u2009=\u20090.051) were independent predictors for MACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that new generation DES for ostial\/midshaft lesions in ULMCA are associated with favorable clinical outcomes, similar to those observed with first generation DES. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25624","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T12:53:34Z","timestamp":1407329614000},"source":"Crossref","is-referenced-by-count":6,"title":["First generation versus new generation drug\u2010eluting stents for the treatment of ostial\/midshaft lesions in unprotected left main coronary artery: The Milan and 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