{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:29:00Z","timestamp":1761863340931},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the predictors of non\u2010healing in patients with critical limb ischemia (CLI) after successful endovascular therapy (EVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Occasionally, wound healing in patients with CLI and tissue loss cannot be achieved even after successful EVT. Patient's co\u2010morbidities, vascular anatomy, wound features, and interventional strategies\/outcomes are associated with the probability of wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 2007 and October 2012, 182 patients with CLI (220 limbs) with tissue loss were treated with EVT in our institute. Of these, 164 individual wounds (130 patients, 149 limbs) out of 243 individual wounds were successfully treated. Successful EVT was defined as revascularization by achieving visible blood flow to the wounds, as evaluated by digital subtraction angiography performed just after EVT. A Cox proportional hazards model was used to analyze predictors associated with wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up period was 23\u2009\u00b1\u200918 months. The wound healing rates were 40.2%, 57.3%, 62.2%, and 70.7% at 3, 6, 9, and 12 months, respectively. Multivariate Cox proportional hazards analysis revealed that insulin use [hazard ratio (HR), 0.541; 95% confidence interval (CI), 0.329\u20130.890; <jats:italic>P<\/jats:italic>\u2009=\u20090.016], dependence on hemodialysis [HR, 0.429; 95% CI, 0.272\u20130.678; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001], and major tissue loss [HR, 0.460; 95% CI, 0.294\u20130.720; <jats:italic>P<\/jats:italic>\u2009=\u20090.001] were independent predictors of non\u2010healing after successful EVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insulin use, dependence on hemodialysis, and major tissue loss were independent predictors of non\u2010healing after successful EVT. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25625","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T12:02:43Z","timestamp":1407326563000},"page":"850-858","source":"Crossref","is-referenced-by-count":14,"title":["Predictors 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