{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:49:23Z","timestamp":1790700563170,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T00:00:00Z","timestamp":1412380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While the current methodology for determining fibrous cap (FC) thickness of lipid plaques is based on manual measurements of arbitrary points, which could lead to high variability and decreased accuracy, it ignores the three\u2010dimensional (3\u2010D) morphology of coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare, utilizing optical coherence tomography (OCT) assessments, volumetric quantification of FC, and macrophage detection using both visual assessment and automated image processing algorithms in non\u2010culprit lesions of STEMI and stable angina pectoris (SAP) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lipid plaques were selected from 67 consecutive patients (1 artery\/patient). FC was manually delineated by a computer\u2010aided method and automatically classified into three thickness categories: FC\u2009&lt;\u200965 \u03bcm (i.e., thin\u2010cap fibroatheroma [TCFA]), 65\u2013150 \u03bcm, and &gt;150 \u03bcm. Minimum thickness, absolute categorical surface area, and fractional luminal area of FC were analyzed. Automated detection and quantification of macrophage was performed within the segmented FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5,503 cross\u2010sections were analyzed. STEMI patients when compared with SAP patients had more absolute categorical surface area for TCFA (0.43\u2009\u00b1\u20090.45 mm<jats:sup>2<\/jats:sup> vs. 0.15\u2009\u00b1\u20090.25 mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.011), thinner minimum FC thickness (31.63\u2009\u00b1\u200917.09 \u00b5m vs. 47.27\u2009\u00b1\u200926.56 \u00b5m, <jats:italic>P<\/jats:italic>\u2009=\u20090.012), greater fractional luminal area for TCFA (1.65\u2009\u00b1\u20091.56% vs. 0.74\u2009\u00b1\u20091.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.046), and greater macrophage index (0.0217\u2009\u00b1\u20090.0081% vs. 0.0153\u2009\u00b1\u20090.0045%, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel OCT\u2010based 3\u2010D quantification of the FC and macrophage demonstrated thinner FC thickness and larger areas of TCFA coupled with more inflammation in non\u2010culprit sites of STEMI compared with SAP. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25660","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T16:34:19Z","timestamp":1409589259000},"source":"Crossref","is-referenced-by-count":13,"title":["Differences determined by optical coherence tomography volumetric analysis in non\u2010culprit lesion morphology and inflammation in ST\u2010segment elevation myocardial infarction and stable angina pectoris patients"],"prefix":"10.1002","volume":"85","author":[{"given":"Micheli Zanotti","family":"Galon","sequence":"first","affiliation":[{"name":"Heart Institute \u2013 InCor, S\u00e3o Paulo University Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiram G.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Core Laboratory Harrington Heart &amp; Vascular Institute, University Hospitals, Case Medical Center Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Alves","family":"Lemos","sequence":"additional","affiliation":[{"name":"Heart Institute \u2013 InCor, S\u00e3o Paulo University Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Schnell","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Core Laboratory Harrington Heart &amp; Vascular Institute, University Hospitals, Case Medical Center Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Costa","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Core Laboratory Harrington Heart &amp; Vascular Institute, University Hospitals, Case Medical Center Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme F.","family":"Attizzani","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Core Laboratory Harrington Heart &amp; Vascular Institute, University Hospitals, Case Medical Center Cleveland Ohio"},{"name":"Department of Interventional Cardiology Pitangueiras Hospital Jundia\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.122475"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.054"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.06.019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000044384.41037.43"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.05.066"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.06.030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.079"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3290810"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000159354.43778.69"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.082"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq518"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.09.022"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32833e1c36"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.062"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn132"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.061"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.001413"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23323"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.243626"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth261"},{"key":"e_1_2_6_23_1","article-title":"C4. 5: Programs for Machine Learning","author":"Quinlan JR","year":"1993","journal-title":"San Diego: Morgan Kaufmann"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00058655"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606310103"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00005.2008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.032"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.782540"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.02.010"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.1070"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.69.5.377"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.36"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.035"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32830042a8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973701"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.25660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.25660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:53:13Z","timestamp":1696575193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.25660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/ccd.25660"],"URL":"https:\/\/doi.org\/10.1002\/ccd.25660","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,4]]}}}