{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:57:20Z","timestamp":1776722240334,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Data are limited regarding transcatheter aortic valve replacement (TAVR)\u2010related thrombocytopenia (TP). We sought to thoroughly characterize the presence, clinical impact, and severity of TP associated with TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Data were collected from 90 patients who underwent TAVR using the Edwards SAPIEN valve (59 TF, 29 TA, 2 Tao). Platelet counts were evaluated peri\u2010procedurally and for 8 days following TAVR. Platelet levels were compared and patients were divided into a no TP (No\u2010TP) group 1, acquired (new) TP (NTP) group 2, pre\u2010existing (pre\u2010TAVR) TP (PTP) group 3, and further stratified based on the severity of TP: mild (M) TP (100\u2013149 \u00d7 10<jats:sup>3<\/jats:sup> cell\/\u00b5L) and moderate\u2013severe (MS) TP (&lt;100 \u00d7 10<jats:sup>3<\/jats:sup> cell\/\u00b5L). Pre\u2010TAVR point prevalence and post\u2010TAVR incidence of TP were 40% and 79%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); nadir platelet count in all groups occurred day 4 post\u2010TAVR. Baseline predictors for developing MS TP in groups 2\u20133 included baseline TP, leaner body mass, smaller pre\u2010procedural aortic valve area, higher peak aortic jet velocity, and worsening baseline renal function. Development of \u201cmajor\u201d TP (nadir platelet count &lt;100 \u00d7 103 cell\/\u00b5L, \u226550% decrease) predicted a higher risk of major vascular complications (OR 2.78 [95% CI, 1.58\u20133.82]) and major bleeding (OR 3.18 [95% CI, 1.33\u20135.42]) in group 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAVR\u2010related TP is predictable and classification by PTP and TP severity prior to TAVR allows for better risk stratification in predicting in\u2010hospital clinical outcomes. Major TP in the presence of worsening TP is predictable and is associated with worse clinical outcomes. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25668","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T04:51:44Z","timestamp":1410324704000},"page":"118-129","source":"Crossref","is-referenced-by-count":37,"title":["Predictors and clinical impact of pre\u2010existing and acquired thrombocytopenia following transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"85","author":[{"given":"Michael P.","family":"Flaherty","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo R.","family":"Bartoli","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Medical Center Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Schneibel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasiq","family":"Rawasia","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville KY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra J.","family":"Grubb","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville KY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn A.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Louisville School of Medicine and Jewish Hospital Rudd Heart and Lung Institute Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698258"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.01.040"},{"key":"e_1_2_6_6_1","first-page":"394","article-title":"Thrombocytopenia after aortic valve replacement: Comparison between mechanical and biological valves","volume":"19","author":"Straten AH","journal-title":"J Heart Valve 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