{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:24:24Z","timestamp":1761765864929},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to compare long\u2010term clinical outcomes in patients treated with new\u2010generation drug\u2010eluting stent (DES) or early\u2010generation DES in a real\u2010world registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>New\u2010generation DESs have proved to be more effective and safer than early\u2010generation DES in randomized trials. However, the effects of new\u2010generation DES versus early\u2010generation DES in everyday clinical practice deserve further verification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A propensity\u2010score and inverse\u2010probability weighted analysis of 5,332 patients undergoing DES implantation (2,557 new\u2010generation and 2,775 early\u2010generation) between January 1, 2007 and June 30, 2011 was performed, with a median follow\u2010up of 3 years. We assessed the incidence of major adverse cardiovascular events (MACE: all\u2010cause death, nonfatal myocardial infarction [MI], and target vessel revascularization [TVR]), and angiographic stent thrombosis (ST) during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3\u2010years, new\u2010generation DES in comparison with early\u2010generation DES were associated with a reduced risk of MI (5% versus 7.4%, hazard ratio [HR]\u2009=\u20090.65, 95% confidence interval [CI]\u2009=\u20090.51\u20130.82, <jats:italic>P<\/jats:italic>\u2009=\u20090.0004) and angiographic ST (0.5% vs. 1.1%, HR\u2009=\u20090.35, 95% CI 0.17\u20130.72, <jats:italic>P<\/jats:italic>\u2009=\u20090.004), whereas, the risk of TVR (10.9% vs. 13.5%; HR 0.99, 95% CI 0.84\u20131.16, <jats:italic>P<\/jats:italic>\u2009=\u20090.99) and overall MACE was not significantly different (19.2% vs. 22.4%, HR\u2009=\u20090.94, 95% CI\u2009=\u20090.83\u20131.07, <jats:italic>P<\/jats:italic>\u2009=\u20090.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data from a large all\u2010comers multicenter registry confirm that, in comparison with early\u2010generation DES, the use of new\u2010generation DES is associated with similar efficacy and increased long\u2010term safety, because of a reduced risk of ST and MI. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25675","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T14:58:22Z","timestamp":1413298702000},"page":"797-806","source":"Crossref","is-referenced-by-count":4,"title":["New\u2010generation drug\u2010eluting stents reduce stent thrombosis and myocardial infarction: A propensity\u2010score\u2010adjusted analysis from the multicenter REAL registry (REgistro Regionale AngiopLastiche Dell'Emilia\u2010Romagna)"],"prefix":"10.1002","volume":"85","author":[{"given":"Luigi","family":"Vignali","sequence":"first","affiliation":[{"name":"Division of Cardiology Azienda Ospedaliero\u2010Universitaria Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[{"name":"Cardiology Institute, Universit\u00e0 di Bologna Policlinico S. Orsola\u2010Malpighi Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Maria Beatrice","family":"Belotti","sequence":"additional","affiliation":[{"name":"Agenzia Sanitaria e Sociale Regionale Regione Emilia\u2010Romagna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Solinas","sequence":"additional","affiliation":[{"name":"Division of Cardiology Azienda Ospedaliero\u2010Universitaria Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Guastaroba","sequence":"additional","affiliation":[{"name":"Agenzia Sanitaria e Sociale Regionale Regione Emilia\u2010Romagna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Laboratorio di Cardiologia Interventistica Ospedale Maggiore Bologna  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Manari","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Cardiologia Interventistica Ospedale Santa Maria Nuova, Reggio Emilia  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine Zena and Michael A. Weiner Cardiovascular Institute New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Ardissino","sequence":"additional","affiliation":[{"name":"Division of Cardiology Azienda Ospedaliero\u2010Universitaria Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"De Palma","sequence":"additional","affiliation":[{"name":"Agenzia Sanitaria e Sociale Regionale Regione Emilia\u2010Romagna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"57","article-title":"Patient selection to enhance the long\u2010term benefit of first generation drug\u2010eluting stents for coronary revascularisation procedures","volume":"5","author":"Saia F","year":"2009","journal-title":"Insights from a large multicentre registry. 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