{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:48:23Z","timestamp":1762098503747,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DFG RA969\/7-2"],"award-info":[{"award-number":["DFG RA969\/7-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p><jats:italic><jats:styled-content>Background:<\/jats:styled-content><\/jats:italic> In patients with mitral regurgitation (MR), changes in cardiac stroke volume, and thus renal preload and afterload may affect kidney function. Percutaneous mitral valve repair (PMVR) with the MitraClip\u00ae system can be a therapeutic alternative to surgical valve repair. The influence of MitraClip\u00ae therapy on renal function and clinical outcome parameters is unknown. <jats:italic><jats:styled-content>Methods and Results:<\/jats:styled-content><\/jats:italic> Sixty patients with severe MR underwent PMVR using the MitraClip\u00ae system in an open\u2010label observational study. Patients were stratified according to their renal function. All clips have been implanted successfully. Effective reduction of MR by 2\u20133 grades acutely improved KDOQI class. Lesser MR reduction (MR reduction of 0\u20131 grades) led to worsening of renal function in patients with pre\u2010existing normal or mild (KDOQI 1\u20132) compared to severe (KDOQI 3\u20134) renal dysfunction. Reduction of MR was associated with improvement in Minnesota Living with Heart Failure Questionnaire (MLHFQ), NYHA\u2010stadium, and 6\u2010minute walk test. <jats:italic><jats:styled-content>Conclusion:<\/jats:styled-content><\/jats:italic> Successful PMVR was associated with an improvement in renal function. The improvement in renal function was associated with the extent of MR reduction and pre\u2010existing kidney dysfunction. Our data emphasize the relevance of PVMR to stabilize the cardiorenal axis in patients with severe MR. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.25705","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T09:13:51Z","timestamp":1413537231000},"page":"899-903","source":"Crossref","is-referenced-by-count":13,"title":["Influence of percutaneous mitral valve repair using the <scp>M<\/scp>itra<scp>C<\/scp>lip\u00ae system on renal function in patients with severe mitral regurgitation"],"prefix":"10.1002","volume":"85","author":[{"given":"Tienush","family":"Rassaf","sequence":"first","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Department of Medicine University Hospital D\u00fcsseldorf, Medical Faculty Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Balzer","sequence":"additional","affiliation":[{"name":"Division of 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