{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:57:09Z","timestamp":1768791429737,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the influence of patients' gender on the outcomes of percutaneous edge\u2010to\u2010edge mitral valve repair (PMVR) using the MitraClip system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although gender\u2010related differences have been extensively documented in patients who undergo surgery for moderate\u2010to\u2010severe (3+) and severe (4+) mitral regurgitation (MR), studies assessing whether these differences exist after PMVR are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and echocardiographic data through 12\u2010month follow up from 171 consecutive patients whom underwent MitraClip implantation and were dichotomized by the gender (106 males and 65 females) were obtained. The primary safety endpoint was the incidence of major adverse events at 30 days and the primary efficacy endpoint was freedom from death, surgery for mitral valve dysfunction, or grade\u2009\u2265\u20093+ MR at 12\u2010month follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary safety endpoint was observed in four males (3.8%) and four females (6.2%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.358). Remarkable reduction in MR postprocedure was revealed in both groups, and these results were mostly sustained. Furthermore, left ventricle reverse remodeling and New York Heart Association (NYHA) functional class improvement were revealed in both groups, but females tended to demonstrate worse results over time (<jats:italic>P<\/jats:italic>\u2009=\u20090.083). The primary efficacy endpoint obtained by Kaplan\u2010Meier estimates was observed in 76.3 and 70.2%, respectively (log rank <jats:italic>P<\/jats:italic>\u2009=\u20090.231).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MitraClip implantation in patients with 3+ and 4+ MR is safe and efficacious until mid\u2010term follow up, regardless of patients' gender. Despite improvement in NYHA functional class in both groups, female gender demonstrated a trend toward poorer results. Further validation of our findings is warranted. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25715","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T12:53:51Z","timestamp":1415105631000},"page":"889-897","source":"Crossref","is-referenced-by-count":33,"title":["Gender\u2010related clinical and echocardiographic outcomes at 30\u2010day and 12\u2010month follow up after <scp>M<\/scp>itra<scp>C<\/scp>lip implantation in the <scp>GRASP<\/scp> registry"],"prefix":"10.1002","volume":"85","author":[{"given":"Guilherme F.","family":"Attizzani","sequence":"first","affiliation":[{"name":"Division of Cardiology Ferrarotto Hospital, University of Catania  Catania Italy"},{"name":"Interventional Cardiology Department Pitangueiras Hospital  Jundia\u00ed Brazil"},{"name":"Harrington Heart and Vascular Institute University Hospitals, Case Medical Center Cleveland 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