{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:29:51Z","timestamp":1761863391807,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009664","name":"Spanish Society of Cardiology","doi-asserted-by":"crossref","award":["SEC-RES-2012-01"],"award-info":[{"award-number":["SEC-RES-2012-01"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with diabetes mellitus (DM) remain at high risk for stent restenosis and adverse cardiovascular events in the drug\u2010eluting stent era. The amphilimus\u2010eluting stent (AES) is a third generation reservoir\u2010based polymer\u2010free drug\u2010eluting stent that has shown promising preliminary results in patients with DM. It has been suggested that the formulation of the drug with fatty acids could not only modulate the drug release in a timely manner but also achieve convenient levels of drug concentration in diabetic cardiac cells. The aim of this trial is to assess the efficacy of the AES in patients with DM compared with the cobalt chromium everolimus\u2010eluting stent with non\u2010erodible polymer (EES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This is an investigator\u2010initiated, multicenter, randomized clinical trial, performed in patients with DM. A total of 112 diabetic patients receiving glucose\u2010lowering agents and requiring percutaneous revascularization of a de novo lesion will be randomized in a 1:1 fashion to receive AES or EES. The primary endpoint is the neointimal volume obstruction at 9 months, evaluated by optical coherence tomography. Secondary endpoints will include strut coverage, angiographic in\u2010stent late loss and clinical endpoints such as target vessel revascularization or probable\/definite stent thrombosis. This study completed the inclusion in October 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The RESERVOIR trial is an investigator\u2010initiated trial that will evaluate whether the polymer\u2010free AES is not inferior to the EES inhibiting the neointimal hyperplasia in patients with DM. These results are also expected to improve our knowledge of the neointimal healing process in this population (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> number NCT01710748). \u00a9 2014 Wiley Periodicals, Inc. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25728","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T08:36:40Z","timestamp":1415349400000},"source":"Crossref","is-referenced-by-count":4,"title":["Rationale and study design of the <scp>RESERVOIR<\/scp> trial: A randomized trial comparing reservoir\u2010based polymer\u2010free amphilimus\u2010eluting stents versus everolimus\u2010eluting stents with durable polymer in patients with diabetes mellitus"],"prefix":"10.1002","volume":"85","author":[{"given":"R.","family":"Romaguera","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart Diseases Institute, Hospital de Bellvitge IDIBELL, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Brugaletta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Institute Hospital Clinic, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gomez\u2010Lara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Diseases Institute, Hospital de Bellvitge IDIBELL, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pinar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Virgen de la Arrixaca Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jim\u00e9nez\u2010Quevedo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute 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