{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:13:07Z","timestamp":1696662787209},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We present a case series of five patients in whom percutaneous paravalvular leak closure with the AVP4 device has been undertaken for symptomatic aortic regurgitation after CoreValve TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Significant post\u2010procedure aortic regurgitation (AR) is often difficult to assess, and is an important predictor of adverse outcome following TAVI. Paravalvular leak closure is an established procedure for surgical aortic prostheses, and has been undertaken for Edwards TAVIs, but has not been described for closure of CoreValve paravalvular leaks.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Methods<\/jats:bold> <jats:bold>and<\/jats:bold> <jats:bold>Results<\/jats:bold><\/jats:title><jats:p>Five patients were treated (mean age 81\u2009\u00b1\u20094 years) with residual grade 3\u20134 AR following placement of a single CoreValve (<jats:italic>n<\/jats:italic>\u2009=\u20092), double CoreValve (<jats:italic>n<\/jats:italic>\u2009=\u20092) or CoreValve within a bioprosthetic AVR (<jats:italic>n<\/jats:italic>\u2009=\u20091). The mean time post TAVI implantation was 308\u2009\u00b1\u2009269 days. All patients were symptomatic with persistent NYHA Grade III dyspnoea. 6 devices were deployed successfully, with mean procedure time of 109\u2009\u00b1\u200923 min. There were no procedural complications and all patients were discharged home by Day 2. Residual AR after treatment was grade 0 (<jats:italic>n<\/jats:italic>\u2009=\u20092), grade 1 (<jats:italic>n<\/jats:italic>\u2009=\u20091), grade 2 (<jats:italic>n<\/jats:italic>\u2009=\u20091) and grade 3 (<jats:italic>n<\/jats:italic>\u2009=\u20091). Symptomatic improvement was noted in all 4 patients who have been reviewed in clinic since.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This small series demonstrates the feasibility of paravalvular leak closure with the CoreValve TAVI, despite the adverse aortic lattice. The AVP4 device is ideally suited to this situation as it will pass through a 0.038' lumen and can therefore be delivered down standard diagnostic catheters. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25730","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T03:53:07Z","timestamp":1415677987000},"page":"657-664","source":"Crossref","is-referenced-by-count":10,"title":["Percutaneous paravalvular leak closure for symptomatic aortic regurgitation after <scp>C<\/scp>ore<scp>V<\/scp>alve transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"85","author":[{"given":"Satpal S.","family":"Arri","sequence":"first","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Poliacikova","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hildick\u2010Smith","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.639450"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.047"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.026"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.049"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.857"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.07.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.048"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.877"},{"key":"e_1_2_6_13_1","first-page":"899","article-title":"German transcatheter aortic valve interventions registry investigators. Aortic regurgitation after transcatheter aortic valve implantation: Incidence and early outcome","volume":"97","author":"Abdel\u2010Wahab M","year":"2011","journal-title":"Results from the German transcatheter aortic valve interventions registry. 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