{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:17:06Z","timestamp":1772180226223,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Heart and Lung Foundation"},{"name":"Swedish Scientific Research Council"},{"name":"Frederik Meijer Heart & Vascular Institute, Spectrum Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was performed to assess the lipid burden of culprit lesions in non\u2010ST\u2010segment elevation myocardial infarction (non\u2010STEMI) and unstable angina (UA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>A recent intracoronary near\u2010infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4\u2010mm (maxLCBI<jats:sub>4mm<\/jats:sub>)\u2009\u2265\u2009400. Whether culprit lesions in non\u2010STEMI and UA are characterized by a similarly large lipid burden is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 81 non\u2010STEMI and UA patients undergoing culprit vessel NIRS imaging before stenting. Culprit segments were compared to all nonoverlapping 10\u2010mm nonculprit segments for maxLCBI<jats:sub>4mm<\/jats:sub>. Culprit segments in non\u2010STEMI and UA were compared for the frequency of maxLCBI<jats:sub>4mm<\/jats:sub>\u2009\u2265\u2009400.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 81 patients (53.1% non\u2010STEMI, 46.9% UA), non\u2010STEMI culprit segments had a 3.4\u2010fold greater maxLCBI<jats:sub>4mm<\/jats:sub> than nonculprits (448\u2009\u00b1\u2009229 vs 132\u2009\u00b1\u2009154, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and UA culprit segments had a 2.6\u2010fold higher maxLCBI<jats:sub>4mm<\/jats:sub> than nonculprits (381\u2009\u00b1\u2009239 vs 146\u2009\u00b1\u2009175, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). NIRS detected a maxLCBI<jats:sub>4mm<\/jats:sub>\u2009\u2265\u2009400 in 63.6% of culprit segments in NSTEMI and in 38.5% of culprit segments in UA (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Against a background of nonculprit segments, maxLCBI<jats:sub>4mm<\/jats:sub>\u2009\u2265\u2009400 had a sensitivity of 63.6% and specificity of 94.0% for culprit segments in NSTEMI and a sensitivity of 38.5% and specificity of 89.8% for culprit segments in UA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Large lipid cores similar to those recently detected by NIRS at STEMI culprit sites were frequently observed at culprit sites in patients with non\u2010STEMI and UA. These findings support ongoing prospective trials designed to determine if NIRS can provide site\u2010specific prediction of future acute coronary events. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25754","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T05:23:39Z","timestamp":1416633819000},"page":"1014-1021","source":"Crossref","is-referenced-by-count":42,"title":["Detection by near\u2010infrared spectroscopy of large lipid cores at culprit sites in patients with non\u2010st\u2010segment elevation myocardial infarction and unstable angina"],"prefix":"10.1002","volume":"86","author":[{"given":"Ryan D.","family":"Madder","sequence":"first","affiliation":[{"name":"Frederik Meijer Heart &amp; Vascular Institute, Spectrum Health Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Husaini","sequence":"additional","affiliation":[{"name":"Frederik Meijer Heart &amp; Vascular Institute, Spectrum Health Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Surgery Michigan State University Lansing Michigan"},{"name":"Research Department Grand Rapids Medical Education Partners Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacie","family":"Van Oosterhout","sequence":"additional","affiliation":[{"name":"Frederik Meijer Heart &amp; Vascular Institute, Spectrum Health Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Harnek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"G\u00f6tberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Erlinge","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1216063"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179739"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.12.1195"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705013361802"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1701"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200109000-00006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.69.5.377"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000159354.43778.69"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.051"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.963934"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.06.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.05.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960200712"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109696.92474.92"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.14.1509"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00872-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2010.01.010"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.09.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200701000-00011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.3.594"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.041798"},{"key":"e_1_2_6_26_1","first-page":"29A","article-title":"The search for vulnerable plaque \u2013 The pace quickens","volume":"25","author":"Madder RD","year":"2013","journal-title":"J Invasive Cardiol"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.25754","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.25754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:56:18Z","timestamp":1696614978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.25754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11,15]]}},"alternative-id":["10.1002\/ccd.25754"],"URL":"https:\/\/doi.org\/10.1002\/ccd.25754","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}