{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:39:35Z","timestamp":1758476375490},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) with the balloon\u2010expandable Sapien transcatheter heart valve improves survival compared to standard therapy in patients with severe aortic stenosis (AS) and is noninferior to surgical aortic valve replacement (AVR) in patients at high operative risk. Nonetheless, a significant proportion of patients may require pre\u2010emptive or emergent support with cardiopulmonary bypass (CPB) and\/or intra\u2010aortic balloon pump (IABP) during TAVR due to pre\u2010existing comorbid conditions or as a result of procedural complications. <jats:bold>Objectives<\/jats:bold>: We hypothesized that patients who required CPB or IABP would have increased periprocedural complications and reduced long\u2010term survival. In addition, we sought to determine whether preprocedural variables could predict the need for CPB and IABP. <jats:bold>Methods<\/jats:bold>: The study population included 2,525 patients in the PARTNER Trial (Cohort A and B) and the continuing access registry (CAR). Patients that received CPB or IABP were compared to patients that did not receive either, and then further divided into those that received support pre\u2010TAVR and those that were placed on support emergently. <jats:bold>Results<\/jats:bold>: One\u2010hundred sixty\u2010three patients (6.5%) were placed on CPB and\/or IABP. The use of CPB or IABP was associated with higher 1 year mortality (49.1% vs. 21.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In multivariable analysis, utilization of CPB or IABP was an independent predictor of 30 day (HR 6.95) and 1\u2010year (HR 2.56) mortality. Although mortality was highest in emergent cases, mortality was also greater in planned CPB and IABP cases compared with non\u2010CPB\/IABP cases (53.3% and 40.3% vs. 21.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). <jats:bold>Conclusions<\/jats:bold>: These findings indicate that CPB and IABP use in TAVR portends a poor prognosis and its utilization, particularly in the setting of pre\u2010emptive use, needs reconsideration. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25776","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T12:29:18Z","timestamp":1419424158000},"page":"316-322","source":"Crossref","is-referenced-by-count":23,"title":["Cardiopulmonary bypass and intra\u2010aortic balloon pump use is associated with higher short and long term mortality after transcatheter aortic valve replacement: A PARTNER trial substudy"],"prefix":"10.1002","volume":"86","author":[{"given":"Satya S.","family":"Shreenivas","sequence":"first","affiliation":[{"name":"Department of Cardiology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M.","family":"Lilly","sequence":"additional","affiliation":[{"name":"Department of Cardiology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson Y.","family":"Szeto","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimesh","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Anwaruddin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Bavaria","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin M.","family":"Hudock","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod H.","family":"Thourani","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Pichard","sequence":"additional","affiliation":[{"name":"Medstar Washington Hospital Center Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Webb","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Dewey","sequence":"additional","affiliation":[{"name":"Medical City Dallas Hospital Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh M.","family":"Suri","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"},{"name":"Columbia University Medical Center\/New York Presbyterian Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard C.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063924"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112471577"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.132209"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61783-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.319"},{"key":"e_1_2_6_9_1","first-page":"517","article-title":"Predictive value of five risk scores to predict outcomes after aortic valve replacement in octogenarians","volume":"22","author":"Vanhuyse F","year":"2013","journal-title":"J Heart 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