{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T22:30:18Z","timestamp":1765837818730},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We studied the prognostic value of plasma N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP)\u2010ratio, which is independent of individual cutoff levels, in predicting mortality in patients undergoing transcatheter aortic valve replacement (TAVR). <jats:bold>Background<\/jats:bold>: Elevated levels of natriuretic peptides are associated with adverse outcomes across a wide spectrum of cardiovascular diseases. However, cutoff values differ according to age, gender, and body weight. <jats:bold>Methods<\/jats:bold>: 244 TAVR patients with preprocedural NT\u2010proBNP levels were analyzed, and the predictive value of NT\u2010proBNP\u2010ratio (measured NT\u2010proBNP\/maximal normal NT\u2010proBNP values specific for age and gender) on all\u2010cause\u2010mortality was assessed in a multivariate model. <jats:bold>Results<\/jats:bold>: Median NT\u2010proBNP\u2010ratio was 4.2 [IQR 1.8\u20139.7]. All\u2010cause mortality at 30 days was 3.4% in patients with less than median NT\u2010proBNP\u2010ratio, and 14.0% in patients with more than median NT\u2010proBNP\u2010ratio (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). All\u2010cause mortality at 1 year was 8.5% in patients with less than median NT\u2010proBNP\u2010ratio, and 32.1% in those with more than median NT\u2010proBNP\u2010ratio (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Cumulative survival declined with increasing quartiles of NT\u2010proBNP\u2010ratio (log rank <jats:italic>P<\/jats:italic>\u2009=\u20090.001). All patients with a NT\u2010proBNP\u2010ratio below 1.5 survived at 1\u2010year follow\u2010up. In ROC analysis, NT\u2010proBNP\u2010ratio significantly predicted 30\u2010day (AUC\u2009=\u20090.72; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and 1\u2010year all\u2010cause mortality (AUC\u2009=\u20090.72; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). By multivariate Cox regression analysis, NT\u2010proBNP\u2010ratio, chronic obstructive pulmonary disease, and serum creatinine were the only independent predictors of all\u2010cause mortality. <jats:bold>Conclusions<\/jats:bold>: Elevated NT\u2010proBNP\u2010ratio was associated with increased short\u2010 and long\u2010term mortality after TAVR, and independently predicted all\u2010cause mortality. NT\u2010proBNP\u2010ratio should be considered in the risk stratification of patients undergoing TAVR. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25788","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T15:34:51Z","timestamp":1418657691000},"page":"1240-1247","source":"Crossref","is-referenced-by-count":24,"title":["N\u2010terminal pro\u2010B\u2010type natriuretic peptide\u2010ratio predicts mortality after transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"85","author":[{"given":"Barbara E.","family":"St\u00e4hli","sequence":"first","affiliation":[{"name":"Department of Cardiology University Heart Center Zurich Switzerlan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cath\u00e9rine","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart Center Zurich 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