{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:00:53Z","timestamp":1760608853678},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>An increased body mass index (BMI) is associated with a high risk of cardiovascular disease and reduction in life expectancy. However, several studies reported improved clinical outcomes in obese patients treated for cardiovascular diseases. The aim of the present study is to investigate the impact of BMI on long\u2010term clinical outcomes after implantation of zotarolimus eluting stents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individual patient data were pooled from the RESOLUTE Clinical Program comprising five trials worldwide. The study population was sorted according to BMI tertiles and clinical outcomes were evaluated at 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from a total of 5,127 patients receiving the R\u2010ZES were included in the present study. BMI tertiles were as follow: I tertile (\u2264 25.95 kg\/m<jats:sup>2<\/jats:sup>\u2014Low or normal weight) 1,727 patients; II tertile (&gt;25.95\u2009\u2264\u200929.74 kg\/m<jats:sup>2<\/jats:sup>\u2014overweight) 1,695 patients, and III tertile (&gt;29.74 kg\/m<jats:sup>2<\/jats:sup>\u2014obese) 1,705 patients. At 2\u2010years follow\u2010up no difference was found for patients with high BMI (III tertile) compared with patients with normal or low BMI (I tertile) in terms of target lesion failure (I\u2013III tertile, HR [95% CI]\u2009=\u20090.89 [0.69, 1.14], <jats:italic>P<\/jats:italic>\u2009=\u20090.341; major adverse cardiac events (I\u2013III tertile, HR [95% CI]\u2009=\u20090.90 [0.72, 1.14], <jats:italic>P<\/jats:italic>\u2009=\u20090.389; cardiac death (I\u2013III tertile, HR [95% CI]\u2009=\u20091.20 [0.73, 1.99], <jats:italic>P<\/jats:italic>\u2009=\u20090.476); myocardial infarction (I\u2013III tertile, HR [95% CI]\u2009=\u20090.86 [0.55, 1.35], <jats:italic>P<\/jats:italic>\u2009=\u20090.509; clinically\u2010driven target lesion revascularization (I\u2013III tertile, HR [95% CI]\u2009=\u20090.75 [0.53, 1.08], <jats:italic>P<\/jats:italic>\u2009=\u20090.123; definite or probable stent thrombosis (I\u2013III tertile, HR [95% CI]\u2009=\u20090.98 [0.49, 1.99], <jats:italic>P<\/jats:italic>\u2009=\u20090.964.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, the patients' body mass index was found to have no impact on long\u2010term clinical outcomes after coronary artery interventions. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25828","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T12:36:41Z","timestamp":1424176601000},"page":"952-958","source":"Crossref","is-referenced-by-count":9,"title":["Impact of body mass index on long\u2010term clinical outcomes after second\u2010generation drug eluting stent implantation: Insights from the international global <scp>RESOLUTE<\/scp> program"],"prefix":"10.1002","volume":"85","author":[{"given":"Roberto","family":"Diletti","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Thoraxcenter, Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector M.","family":"Garcia\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Thoraxcenter, Erasmus MC Rotterdam The Netherlands"},{"name":"Cardialysis B.V. 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